Search research articles

ABOUT JoVE

Overview Leadership Blog JoVE Help Center

AUTHORS

Publishing Process Editorial Board Scope & Policies Peer Review FAQ Submit

LIBRARIANS

Testimonials Subscriptions Access Resources Library Advisory Board FAQ

RESEARCH

JoVE Journal Methods Collections JoVE Encyclopedia of Experiments Archive

EDUCATION

JoVE Core JoVE Business JoVE Science Education JoVE Lab Manual Faculty Resource Center Faculty Site

Terms & Conditions of Use

Related Concept Videos

Cerebrospinal Fluid

Cerebrospinal Fluid

Cerebrospinal fluid (CSF) is a colorless liquid that flows around the brain and the spinal cord, playing a vital role in the protection, support, and overall function of the central nervous system (CNS). CSF production, circulation, and absorption are tightly regulated processes essential for the brain and spinal cord to function properly.
CSF Production
CSF is produced mainly in the choroid plexus, a network of capillaries and ependymal cells located within the ventricular system of the brain....

Spinal Cord: Gross Anatomy

Spinal Cord: Gross Anatomy

The spinal cord resides within the protective confines of the vertebral column. It is the main pathway for information traveling between the brain and the body. It plays a fundamental role in nearly all bodily functions, from simple reflexes to complex motor movements. The spinal cord begins at the medulla oblongata at the base of the brainstem and extends downward, terminating at the conus medullaris near the first and second lumbar vertebrae. The spinal cord's length in adults is...

Spinal Cord: Information Processing

Spinal Cord: Information Processing

The spinal cord is an integral hub for motor and sensory information that enables the brain to communicate with the peripheral nervous system (PNS). This communication consists of relaying sensory data and transmission of motor commands.
Sensory Information Processing
Sensory information processing begins at the sensory receptors located in the skin and other tissues, which detect somatic sensory stimuli such as touch, temperature, or pain. These receptors function as catalysts, initiating...

Peripheral Nervous System: Ganglia and Nerves

Peripheral Nervous System: Ganglia and Nerves

The Peripheral Nervous System (PNS) is a crucial component of the body's neural network, extending beyond the central nervous system (CNS) to bridge the gap between the CNS and the external environment. It encompasses nerves, ganglia, and sensory receptors.
Nerves
The nerve is a bundle of axons that serves as the communication highway in the PNS. Each nerve is ensheathed in a protective layer of connective tissue called the epineurium. This outermost layer safeguards the nerve and supports the...

Spinal Cord

Spinal Cord

The spinal cord, a critical component of the central nervous system, extends from the base of the brainstem to the lumbar region of the vertebral column. It is essential for maintaining physical stability and facilitating communication between the brain and peripheral parts of the body.

The Spinal Cord

The Spinal Cord

The spinal cord is the body’s major nerve tract of the central nervous system, communicating afferent sensory information from the periphery to the brain and efferent motor information from the brain to the body. The human spinal cord extends from the hole at the base of the skull, or foramen magnum, to the level of the first or second lumbar vertebra.

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by

Same author

Buccal Fat Suspension: Not Just a Lift-Restoring the Foundational Anatomy of a Youthful Cheek.

Aesthetic surgery journal·2026

Same author

Evaluating the effects of aging on distribution and gene silencing activity of lipid-siRNA conjugates delivered into cerebrospinal fluid.

Molecular therapy : the journal of the American Society of Gene Therapy·2026

Same author

A case of orbital solitary fibrous tumor with fast-growing budding morphology.

Orbit (Amsterdam, Netherlands)·2026

Same author

Investigation of a viable but non-culturable state in Porphyromonas gingivalis and host cell invasion.

PloS one·2026

Same author

Evaluating the effects of aging on biodistribution and gene silencing activity of lipid-siRNA conjugates delivered into cerebrospinal fluid.

bioRxiv : the preprint server for biology·2025

Same author

Repeat-associated non-AUG translation as a common mechanism for the polyGln ataxias.

Cell reports·2025

Same journal

A human-specific genetic modifier reconfigures large-scale cortical network dynamics underlying behavioral performance.

bioRxiv : the preprint server for biology·2026

Same journal

<i>Staphylococcus aureus</i> uses a eukaryotic-like uridyltransferase to make UDP-GlcNAc for cell wall synthesis.

bioRxiv : the preprint server for biology·2026

Same journal

Dynamic redistribution of eIF4F controls cap-dependent translation initiation.

bioRxiv : the preprint server for biology·2026

Same journal

When does additional information improve accuracy of RNA secondary structure prediction?

bioRxiv : the preprint server for biology·2026

Same journal

Normative brain-state trajectories reveal deviation from healthy aging in Alzheimer's disease.

bioRxiv : the preprint server for biology·2026

Same journal

Noradrenergic infraslow rhythm during sleep is the critical link between heart-rate dynamics and memory consolidation.

bioRxiv : the preprint server for biology·2026

See all related articles

Search research articles

Related Experiment Video

Updated: Jul 9, 2025

Three-Dimensional Imaging of the Vertebral Lymphatic Vasculature and Drainage using iDISCO+ and Light Sheet Fluorescence Microscopy

Three-Dimensional Imaging of the Vertebral Lymphatic Vasculature and Drainage using iDISCO+ and Light Sheet Fluorescence Microscopy

Published on: May 22, 2020

Cerebrospinal Fluid Flow Extends to Peripheral Nerves.

Alexander P Ligocki, Augustine V Vinson, Anthony T Yachnis

Biorxiv : the Preprint Server for Biology

|December 4, 2023

Summary

This summary is machine-generated.

Cerebrospinal fluid (CSF) flows beyond the brain and spinal cord into peripheral nerves. This discovery reveals a contiguous fluid system vital for nerve health and waste removal.

More Related Videos

In Vivo Imaging of Cerebrospinal Fluid Transport through the Intact Mouse Skull using Fluorescence Macroscopy

In Vivo Imaging of Cerebrospinal Fluid Transport through the Intact Mouse Skull using Fluorescence Macroscopy

Published on: July 29, 2019

Cannula Implantation into the Cisterna Magna of Rodents

Cannula Implantation into the Cisterna Magna of Rodents

Published on: May 23, 2018

Related Experiment Videos

Last Updated: Jul 9, 2025

Three-Dimensional Imaging of the Vertebral Lymphatic Vasculature and Drainage using iDISCO+ and Light Sheet Fluorescence Microscopy

Three-Dimensional Imaging of the Vertebral Lymphatic Vasculature and Drainage using iDISCO+ and Light Sheet Fluorescence Microscopy

Published on: May 22, 2020

In Vivo Imaging of Cerebrospinal Fluid Transport through the Intact Mouse Skull using Fluorescence Macroscopy

In Vivo Imaging of Cerebrospinal Fluid Transport through the Intact Mouse Skull using Fluorescence Macroscopy

Published on: July 29, 2019

Cannula Implantation into the Cisterna Magna of Rodents

Cannula Implantation into the Cisterna Magna of Rodents

Published on: May 23, 2018

Area of Science:

Neuroscience
Physiology

Background:

Cerebrospinal fluid (CSF) supports the central nervous system (CNS) but its presence in peripheral nerves is unknown.
Peripheral nerves have a three-layer covering analogous to the CNS meninges.

Approach:

Gold nanoparticles were used to trace fluid pathways in peripheral nerves.
The continuity between CSF and endoneurial fluid was investigated.

Key Points:

Cerebrospinal fluid (CSF) flow extends contiguously from the CNS into peripheral nerves.
The endoneurial space within peripheral nerves is identified as the primary site of CSF flow.
Nanoparticle distribution indicates CSF's role in nutrient delivery and waste clearance in the periphery.

Conclusions:

The nervous system possesses a unified fluid system encompassing both CNS and peripheral nerves.
CSF plays a critical role in maintaining peripheral nerve health and function.