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A Whole Food, Plant-Based Randomized Controlled Trial in Metastatic Breast Cancer: Feasibility, Nutrient, and
Erin K Campbell1, Thomas M Campbell1, Eva Culakova1
1University of Rochester Medical Center.
Research Square
|December 4, 2023
Summary
A whole food, plant-based (WFPB) diet intervention improved quality of life (QOL) in women with metastatic breast cancer (MBC). This dietary approach enhanced cognitive function and emotional well-being while reducing fatigue.
Area of Science:
- Oncology
- Nutrition Science
- Quality of Life Research
Background:
- Quality of life (QOL) is a critical outcome for patients with metastatic breast cancer (MBC), significantly impacted by cognitive impairment, fatigue, and weight gain.
- Assessing the feasibility and impact of dietary interventions on QOL in MBC patients is crucial for supportive care.
Approach:
- A randomized controlled trial allocated women with MBC to a whole food, plant-based (WFPB) diet intervention or usual care for 8 weeks.
- The WFPB intervention involved weekly education sessions and provided daily meals, focusing on dietary changes.
- Outcomes, including patient-reported measures and dietary intake, were assessed at baseline and 8 weeks.
Key Points:
- High adherence (94.3%) to the WFPB diet was observed, with significant reductions in dietary fat and increases in fiber intake.
- Intervention participants showed significant improvements in perceived cognitive function (FACT-Cog) and emotional well-being (FACT-B).
- The WFPB diet group also experienced significant reductions in fatigue severity and fatigue at its worst (BFI).
Conclusions:
- Implementing significant dietary changes, such as a WFPB diet, is feasible for women with MBC.
- This dietary intervention may improve QOL by mitigating treatment-related symptoms like cognitive impairment, fatigue, and emotional distress.
- Further research is warranted to confirm these findings and explore long-term effects.
Keywords:
breast cancermetastatic breast cancernutritionobesitypatient-reported outcomesplant-basedquality of lifevegan dietMore Related Videos
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