Sex differences in intrinsic functional cortical organization reflect differences in network topology rather than
Bianca Serio1,2,3,4, Meike D Hettwer1,2,3,4, Lisa Wiersch3,4
1Max Planck School of Cognition, Leipzig, Germany.
Biorxiv : the Preprint Server for Biology
|December 4, 2023
Summary
Sex differences in brain function are not solely explained by brain size or structure. Functional connectivity and network topology play a key role in intrinsic cortical organization differences between sexes.
Area of Science:
- Neuroscience
- Brain Imaging
- Sex Differences
Background:
- Brain size robustly differs between sexes, a phenomenon known as anatomical dimorphism.
- The impact of this dimorphism on intrinsic brain function remains unclear.
- Understanding sex differences in brain organization is crucial for neuroscience research.
Conclusions:
- Sex differences in intrinsic cortical functional organization extend beyond anatomical and microstructural differences.
- Functional connectivity and network topology are key factors in understanding sex-based variations in brain function.
- Findings challenge the assumption that morphometric differences fully explain functional sex disparities in the brain.
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