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Measurement of Protein Turnover Rates in Senescent and Non-Dividing Cultured Cells with Metabolic Labeling and Mass Spectrometry

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Transcriptional drift in aging cells: A global de-controller.

Tyler Matsuzaki¹, Corey Weistuch², Adam de Graff¹

¹Stony Brook University.

Biorxiv : the Preprint Server for Biology

|December 4, 2023

Summary

Cellular aging involves widespread gene expression changes, known as transcriptional drift. This study reveals that aging cells upregulate stress-response genes and downregulate growth genes, suggesting a coordinated aging process.

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Area of Science:

Molecular Biology
Gerontology
Genetics

Background:

Cellular aging is characterized by significant alterations in gene expression patterns.
Understanding the coordinated changes in gene expression during aging is crucial for developing interventions.

Approach:

Utilized archetype modeling and Gene Ontology analysis on aging *Caenorhabditis elegans* data.
Investigated global gene expression shifts, specifically transcriptional drift, during the aging process.

Key Points:

Aging cells exhibit widespread gene overexpression and underexpression (transcriptional drift).
Upregulated genes in aging worms are linked to sensory proteins and stress responses.
Downregulated genes are associated with growth and metabolism.

Conclusions:

A single, age-concentrating ligand may mechanistically coordinate these global expression changes.
Cellular responses are integral to aging, implying potential for therapeutic modulation.
This coordinated aging mechanism differs from simple wear-and-tear processes.