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Updated: Jul 9, 2025

Imaging Features of Systemic Sclerosis-Associated Interstitial Lung Disease
Published on: June 16, 2020
An unusual cause of progressive dyspnoea, pulmonary nodules and pleural effusions
Sudharsan Venkatesan1,2, Bharti Ramnani3, Sonja Klebe2,4
1Division of Medicine Royal Darwin Hospital Darwin Northern Territory Australia.
Abstract:
Eosinophilic granulomatosis with polyangiitis (EGPA) is part of the ANCA-associated vasculitides, although ANCA-negative presentations are not infrequent. Asthma, allergic rhinitis and peripheral eosinophilia are classic associations although pleural effusions are an uncommon manifestation of EGPA. We describe a 35-year old Caucasian adult with asthma who presented with progressive dyspnoea, cough, peripheral eosinophilia and imaging that showed pulmonary nodules with pleural effusions. Biopsy with histopathological review confirmed the diagnosis of EGPA with steroid therapy resulting in significant resolution of symptoms and imaging findings.
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