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Why do we keep ignoring sex in kidney disease?
Magdalena Jankowska1, María José Soler2, Kate I Stevens3
1Department of Nephrology, Transplantology and Internal Medicine, Faculty of Medicine, Medical University of Gdansk, Gdańsk, Poland.
Clinical Kidney Journal
|December 4, 2023
Summary
Understanding sex and gender differences in kidney disease is crucial for accurate diagnosis and effective management. Addressing these disparities improves patient care and outcomes in nephrology.
Area of Science:
- Nephrology
- Sex and Gender Differences in Medicine
Background:
- Historically, sex and gender differences in kidney disease have been overlooked, hindering optimal patient care.
- Precision medicine necessitates understanding these differential factors for improved diagnosis and management.
Purpose of the Study:
- To review current literature on sex and gender disparities in kidney disease.
- To identify knowledge gaps and areas for future research in nephrology.
- To raise awareness of gender-based healthcare disparities.
Main Methods:
- Literature review and synthesis of existing research on sex and gender in kidney disease.
- Analysis of epidemiological data, treatment risks, and diagnostic impacts.
- Exploration of gender-related disparities in healthcare systems.
Main Results:
- Sex-specific effects on chronic kidney disease epidemiology are noted.
- Women face risks of dialysis underdosing and medication overdosing.
- The female survival advantage diminishes during dialysis, and gender impacts genetic kidney disease management.
Conclusions:
- Integrating sex and gender considerations into nephrology practice can enhance patient care and outcomes.
- Further research is needed to develop targeted prevention and intervention strategies.
- Addressing gender-based disparities is essential for equitable kidney healthcare.
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