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Extraction of Plant-based Capsules for Microencapsulation Applications

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Zein-Induced Polyelectrolyte Complexes for Encapsulating Triterpenoid Phytochemicals.

Yong-Jin Kim¹, Eun-Soo Lee¹, Joonho Choi¹

¹Research and Innovation Unit, AMOREPACIFIC, Yonggu-daero, Giheung-gu, Yongin-si, Gyeonggi-do 1920, Republic of Korea.

|December 4, 2023

Summary

Researchers developed a novel zein-induced polyelectrolyte (ZiP) complex to overcome zein

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Area of Science:

Biopolymer science
Drug delivery systems
Phytochemical encapsulation

Background:

Zein's hydrophobicity and aggregation hinder its use as a drug carrier.
Developing effective delivery systems for phytochemicals like compound K is crucial.

Purpose of the Study:

To create and evaluate a zein-induced polyelectrolyte (ZiP) complex for delivering compound K.
To assess the physical properties, encapsulation efficiency, and stability of the ZiP complex.

Main Methods:

Formulated ZiP complexes using self-assembled zein, pullulan, and pectin.
Investigated the effects of varying component ratios on complex formation and stability.
Assessed encapsulation efficiency, particle size, and stability at different temperatures and over time.

Main Results:

Achieved 99.6% encapsulation efficiency for compound K with a particle size of 294.8 nm.
ZiP complexes showed enhanced stability at 25 °C and 45 °C.
Demonstrated long-term stability of encapsulated saponin for over 24 weeks.

Conclusions:

ZiP complexes effectively encapsulate compound K, overcoming zein's limitations.
The developed system offers enhanced stability and potential for improved *in vivo* absorption of phytochemicals.
ZiP complexes represent a promising drug delivery system for industrial formulation development.