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Correction: Maurer et al. Gut Microbial Disruption in Critically Ill Patients with COVID-19-Associated Pulmonary Aspergillosis. <i>J. Fungi</i> 2022, <i>8</i>, 1265.

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Modeling microbiota-associated human diseases: from minimal models to complex systems.

Doriane Aguanno1, Amira Metwaly1, Olivia I Coleman1

  • 1Chair of Nutrition and Immunology, Technical University of Munich, Freising 85354, Germany.

Microbiome Research Reports
|December 4, 2023
PubMed
Summary
This summary is machine-generated.

Alterations in human gut microbiota are linked to obesity, inflammatory bowel diseases (IBD), and colorectal cancer (CRC). Human microbiota-associated mouse models help study the microbiome

Keywords:
Human microbiota-associated mouse modelscolorectal cancerfecal microbiota transplantationhost-microbiota interactionsinflammatory bowel diseasesmetabolic diseasesobesity

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Area of Science:

  • Microbiome research
  • Gastrointestinal disease pathogenesis
  • Animal modeling

Background:

  • Gut microbiota alterations correlate with obesity, IBD, and CRC.
  • These diseases show modified microbial richness, composition, and function.
  • Germ-free animal models confirm microbiota's causal role in disease.

Purpose of the Study:

  • To review methods for validating bacterial contributions to human diseases.
  • Emphasis on obesity, IBD, and CRC.
  • Focus on human microbiota-associated mouse models.

Main Methods:

  • Review of in vitro fermentation systems.
  • Ex vivo intestinal organoid models.
  • Human microbiota-associated mouse models.

Main Results:

  • Human microbiota-associated models are crucial for studying disease pathogenesis.
  • These models are increasingly used for IBD and CRC research.
  • Discussion of advantages and limitations of current models.

Conclusions:

  • Human microbiota-associated models offer powerful tools for mechanistic studies.
  • Refinement of models is needed to mimic human microbiota complexity.
  • These models are vital for understanding dysbiosis in digestive diseases.