A keratotic nodule on a cobblestone plaque: A rare case presentation

Area of Science:

• Dermatology
• Pathology
• Histopathology

Background:

• Perforating calcific elastosis is a rare, acquired skin disorder.
• It typically affects middle-aged, multiparous, and obese women.

Observation:

• A 68-year-old woman presented with a pruritic nodule and a yellow, cobblestone-like plaque on her abdomen.
• Dermatological examination revealed characteristic skin changes.

Findings:

• Biopsy demonstrated transepidermal elimination of basophilic elastic fibers within the reticular dermis.
• Microscopic analysis confirmed the presence of significant calcium deposits.

Implications:

• This case highlights the histopathological features crucial for diagnosing perforating calcific elastosis.
• Understanding the condition's rarity and typical demographic is important for clinical suspicion.