Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

The effect of dietary omega-6 fatty acid enrichment in rodent models of military-relevant acute traumatic psychological stress and traumatic brain injury.

Frontiers in microbiomes·2026
Same author

Comparison of blood-brain barrier permeability changes in gyrencephalic (ferret & non-human primate) and lissencephalic (rat) models following blast overpressure exposures.

Experimental neurology·2025
Same author

Repeated Mild Concussive Events Heighten the Vulnerability of Brain to Blast Exposure.

Journal of neurotrauma·2023
Same author

Upregulation of multiple toll-like receptors in ferret brain after blast exposure: Potential targets for treatment.

Neuroscience letters·2023
Same author

Cerebrospinal Fluid Levels of Lysophosphatidic Acids Can Provide Suitable Biomarkers of Blast-Induced Traumatic Brain Injury.

Journal of neurotrauma·2023
Same author

Soft-armor Vest Effectiveness and Intrathoracic Biomechanics in Rodents Exposed to Primary Blast.

Annals of biomedical engineering·2023

Related Experiment Video

Updated: Jul 9, 2025

High Resolution Quantitative Synaptic Proteome Profiling of Mouse Brain Regions After Auditory Discrimination Learning
10:36

High Resolution Quantitative Synaptic Proteome Profiling of Mouse Brain Regions After Auditory Discrimination Learning

Published on: December 15, 2016

10.6K

Blast Exposure Alters Synaptic Connectivity in the Mouse Auditory Cortex.

Ying Wang1, Yanling Wei1, Ming Ren2

  • 1Blast-Induced Neurotrauma Branch, Center for Military Psychiatry and Neuroscience, Walter Reed Army Institute of Research, Silver Spring, Maryland, USA.

Journal of Neurotrauma
|December 4, 2023
PubMed
Summary

Blast exposure damages central auditory pathways, affecting hearing. This study reveals impaired synaptic connectivity in the auditory cortex after blast, offering insights into hearing loss and potential treatments.

Keywords:
blast exposurecenter for auditory signal processinginjurysynaptic connectivity

More Related Videos

Author Spotlight: Deciphering the Long-Term Effects of Low-Level Blast Exposures in Mice
06:00

Author Spotlight: Deciphering the Long-Term Effects of Low-Level Blast Exposures in Mice

Published on: May 24, 2024

942
Stereotactically-guided Ablation of the Rat Auditory Cortex, and Localization of the Lesion in the Brain
09:29

Stereotactically-guided Ablation of the Rat Auditory Cortex, and Localization of the Lesion in the Brain

Published on: October 11, 2017

11.6K

Related Experiment Videos

Last Updated: Jul 9, 2025

High Resolution Quantitative Synaptic Proteome Profiling of Mouse Brain Regions After Auditory Discrimination Learning
10:36

High Resolution Quantitative Synaptic Proteome Profiling of Mouse Brain Regions After Auditory Discrimination Learning

Published on: December 15, 2016

10.6K
Author Spotlight: Deciphering the Long-Term Effects of Low-Level Blast Exposures in Mice
06:00

Author Spotlight: Deciphering the Long-Term Effects of Low-Level Blast Exposures in Mice

Published on: May 24, 2024

942
Stereotactically-guided Ablation of the Rat Auditory Cortex, and Localization of the Lesion in the Brain
09:29

Stereotactically-guided Ablation of the Rat Auditory Cortex, and Localization of the Lesion in the Brain

Published on: October 11, 2017

11.6K

Area of Science:

  • Neuroscience
  • Auditory Neuroscience
  • Blast Injury Research

Background:

  • Blast exposure causes significant auditory deficits.
  • Central auditory processing impacts are largely undefined.
  • Understanding central nervous system (CNS) alterations is key for therapeutic interventions.

Purpose of the Study:

  • Investigate synaptic connectivity impairment in the auditory cortex (AC) after blast exposure.
  • Elucidate structural and functional changes in the CNS following blast injuries.
  • Identify potential therapeutic targets for blast-induced auditory dysfunction.

Main Methods:

  • Electrophysiology
  • Optogenetics assay
  • Proteomic analysis
  • Morphological evaluation in mice

Main Results:

  • Impaired long-range functional connectivity between the medial geniculate nucleus (MGN) and AC in the acute phase.
  • Synaptic transmission and dendritic spine alterations observed within 7 days post-blast, recovering by 28 days.
  • Differentially expressed proteins related to synaptic signaling and plasticity identified in the cortex.

Conclusions:

  • Blast-induced alterations in the auditory cortex sound signaling network contribute to hearing deficits.
  • Findings suggest potential therapeutic windows for improving auditory outcomes in blast-exposed individuals.
  • Provides insights into the pathophysiology of blast-induced auditory dysfunction.