Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Radiological Investigation I: X-ray and CT01:30

Radiological Investigation I: X-ray and CT

245
Radiological investigations, including X-rays and computed tomography (CT) scans, are critical for diagnosing and evaluating various medical conditions. These imaging techniques provide valuable insights into the body's internal structures, aiding in the detection of abnormalities, assessment of disease progression, and development of treatment strategies. This article delves into two primary radiological investigations, chest X-rays and CT scans, outlining their purpose, procedures, and...
245
Positron Emission Tomography01:29

Positron Emission Tomography

4.2K
Positron emission tomography (PET) is a medical imaging technique involving radiopharmaceuticals — substances that emit short-lived radiation. Although the first PET scanner was introduced in 1961, it took 15 more years before radiopharmaceuticals were combined with the technique and revolutionized its potential.
One of the main requirements of a PET scan is a positron-emitting radioisotope, which is produced in a cyclotron and then attached to a substance used by the part of the body...
4.2K
Imaging Studies II: Positron Emission Tomography and Scintigraphy01:25

Imaging Studies II: Positron Emission Tomography and Scintigraphy

123
Positron Emission Tomography (PET) is a medical imaging technique that provides crucial insights into the body's physiological functions at a molecular level. It is an indispensable resource for diagnosing, staging, and monitoring various illnesses, notably cancer, neurological disorders, and cardiovascular conditions.
Fundamental Principles of PET
123
Computed Tomography01:10

Computed Tomography

4.5K
Tomography refers to imaging by sections. Computed tomography (CT) is a non-invasive imaging technique that uses computers to analyze several cross-sectional X-rays to reveal minute details about structures in the body.
The technique was invented in the 1970s and is based on the principle that as X-rays pass through the body, they are absorbed or reflected at different levels. In the technique, a patient lies on a motorized platform while a computerized axial tomography (CAT) scanner rotates...
4.5K
Radiological Investigation III: Pulmonary Angiogram and PET Scan01:13

Radiological Investigation III: Pulmonary Angiogram and PET Scan

95
Radiological investigations are paramount in the diagnosis and management of various pulmonary diseases. Two essential investigations are the Pulmonary Angiogram and the Positron Emission Tomography (PET) Scan.
Pulmonary Angiogram
A Pulmonary Angiogram is an invasive procedure involving injecting a contrast medium through a catheter threaded into the pulmonary artery or the right side of the heart to visualize the pulmonary vasculature. Computed Tomography (CT) scans have mainly replaced this...
95

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Long vs. short axial field-of-view PET scanners for brain imaging: a phantom study.

Frontiers in nuclear medicine·2026
Same author

Total Body PET.

Recent results in cancer research. Fortschritte der Krebsforschung. Progres dans les recherches sur le cancer·2026
Same author

Validation of a Deep-Learning Coregistration Framework for Long-Axial-Field-of-View PET/CT Using Low-Radiation-Exposure Protocols Across Various Tracers.

Journal of nuclear medicine : official publication, Society of Nuclear Medicine·2026
Same author

Developing Topics.

Alzheimer's & dementia : the journal of the Alzheimer's Association·2025
Same author

Delayed [<sup>89</sup>Zr]Zr-<i>N</i>-Succinyldesferal-Trastuzumab Imaging Enabled by Long-Axial-Field-of-View PET/CT.

Journal of nuclear medicine : official publication, Society of Nuclear Medicine·2025
Same author

Influence of Ultra-Low-Dose CT on PET Image Quantification and Visual Assessment.

Journal of nuclear medicine : official publication, Society of Nuclear Medicine·2025

Related Experiment Video

Updated: Jul 9, 2025

High-Resolution Cardiac Positron Emission Tomography/Computed Tomography for Small Animals
11:09

High-Resolution Cardiac Positron Emission Tomography/Computed Tomography for Small Animals

Published on: December 16, 2022

3.7K

Ultra-low dose CT scanning for PET/CT.

Samaneh Mostafapour1, Marcel Greuter2, Johannes H van Snick1

  • 1Nuclear Medicine and Molecular Imaging, University of Groningen, University Medical Center Groningen, Groningen, The Netherlands.

Medical Physics
|December 4, 2023
PubMed
Summary

This study demonstrates that using a tin (Sn) filter in computed tomography (CT) significantly reduces radiation dose for positron emission tomography/computed tomography (PET/CT) scans. The dose reduction minimally impacts PET image quality, making it suitable for routine clinical use.

Keywords:
PET/CTdose reductionlong-axial-field-of-viewtin filtertotal body PET

More Related Videos

Radiosynthesis, Quality Control, and Small Animal Positron Emission Tomography Imaging of 68Ga-Labelled Nano Molecules
09:55

Radiosynthesis, Quality Control, and Small Animal Positron Emission Tomography Imaging of 68Ga-Labelled Nano Molecules

Published on: October 4, 2024

401
Continuous Blood Sampling in Small Animal Positron Emission Tomography/Computed Tomography Enables the Measurement of the Arterial Input Function
10:21

Continuous Blood Sampling in Small Animal Positron Emission Tomography/Computed Tomography Enables the Measurement of the Arterial Input Function

Published on: August 8, 2019

8.4K

Related Experiment Videos

Last Updated: Jul 9, 2025

High-Resolution Cardiac Positron Emission Tomography/Computed Tomography for Small Animals
11:09

High-Resolution Cardiac Positron Emission Tomography/Computed Tomography for Small Animals

Published on: December 16, 2022

3.7K
Radiosynthesis, Quality Control, and Small Animal Positron Emission Tomography Imaging of 68Ga-Labelled Nano Molecules
09:55

Radiosynthesis, Quality Control, and Small Animal Positron Emission Tomography Imaging of 68Ga-Labelled Nano Molecules

Published on: October 4, 2024

401
Continuous Blood Sampling in Small Animal Positron Emission Tomography/Computed Tomography Enables the Measurement of the Arterial Input Function
10:21

Continuous Blood Sampling in Small Animal Positron Emission Tomography/Computed Tomography Enables the Measurement of the Arterial Input Function

Published on: August 8, 2019

8.4K

Area of Science:

  • Medical Imaging Physics
  • Radiological Sciences
  • Nuclear Medicine Technology

Background:

  • Computed tomography (CT) for attenuation correction (AC) in positron emission tomography/computed tomography (PET/CT) contributes significantly to patient radiation exposure.
  • This radiation dose is a limiting factor for dose reduction in whole-body PET/CT, especially with long axial field of view (LAFOV) scanners.
  • Tin (Sn) filter technology offers a potential solution for substantially reducing CT radiation dose.

Purpose of the Study:

  • To investigate ultra-low dose CT protocols for AC in LAFOV PET/CT using Sn filters and tube current (mAs) reduction.
  • To evaluate the impact of CT dose reduction on PET image quality.

Main Methods:

  • Evaluated ultra-low dose CT protocols on five physical phantoms using a LAFOV PET/CT scanner.
  • Applied dose reduction techniques: reduced tube current (mAs), increased pitch, and Sn filter application.
  • Assessed effective dose using CTDIvol and compared PET/CT images and attenuation maps against standard low-dose CT protocols.

Main Results:

  • Sn filter and lowest mAs reduced CT radiation dose to nearly 2% of routine low-dose CT protocols.
  • PET image quantification showed relative differences under 6% for mean activity concentration in torso phantoms and patient datasets.
  • Adjusting tube current (6-30 mAs) in patients with high BMI or arms down suppressed artifacts while maintaining 90% dose reduction.

Conclusions:

  • Sn filter application in CT imaging reduces radiation dose by over 90%.
  • This dose reduction minimally affects PET image quantification for patients with Body Mass Index (BMI) ≤ 30.
  • Further validation with larger clinical PET/CT datasets, including patients with higher BMI, is recommended.