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Updated: Jul 9, 2025
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A Murine Model of Fetal Exposure to Maternal Inflammation to Study the Effects of Acute Chorioamnionitis on Newborn Intestinal Development
Published on: June 24, 2020
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Chorioamnionitis, Cesarean Deliveries, and Racial Disparities in the USA
Injy El-Dib1,2, Mohsen A A Farghaly3, Firas Saker1
1Cleveland Clinic Children's, 9500 Euclid Avenue #M31, Cleveland, OH, 44195, USA.
Journal of Racial and Ethnic Health Disparities
|December 4, 2023
Summary
African American women have higher rates of cesarean delivery (CD) compared to Caucasian women, even after accounting for chorioamnionitis. These ethnic disparities in CD rates require further investigation into underlying causes.
Area of Science:
- Obstetrics
- Maternal-Fetal Medicine
- Health Disparities
Background:
- Studies indicate disparities in management and outcomes between African American and Caucasian populations.
- Chorioamnionitis may influence cesarean delivery (CD) decisions, but its interaction with maternal race/ethnicity is unclear.
Purpose of the Study:
- To assess the interaction between African American race/ethnicity and cesarean delivery (CD) in women diagnosed with chorioamnionitis.
Main Methods:
- Analysis of the National Inpatient Sample dataset.
- Examination of the association between CD and chorioamnionitis in overall, Caucasian, and African American populations.
- Logistic regression models were employed to control for confounding variables.
Main Results:
- The study included over 6.6 million deliveries.
- Chorioamnionitis prevalence was higher in African American (1.1%) versus Caucasian (0.78%) women.
- African American women exhibited significantly higher rates of CD, even after adjusting for chorioamnionitis and other confounders (aOR 1.18).
Conclusions:
- Chorioamnionitis is associated with an increased rate of cesarean delivery.
- Ethnic disparities in CD rates persist, irrespective of chorioamnionitis status.
- Further research is warranted to understand the factors contributing to these observed racial/ethnic discrepancies in CD rates.
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