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Burden of atopic dermatitis in paediatric patients: an international cross-sectional study

Stephan Weidinger1, Eric L Simpson2, Jonathan I Silverberg3

  • 1Department of Dermatology, Allergology and Venereology, University Hospital Schleswig-Holstein, Campus Kiel, Kiel, Germany.

The British Journal of Dermatology
|December 4, 2023
PubMed

Insights

Atopic dermatitis (AD) significantly impacts children and adolescents, with moderate-to-severe cases causing more itch, pain, sleep issues, and missed school days. Assessments should consider AD's functional impact.

Area of Science:

  • Dermatology
  • Pediatrics
  • Public Health

Background:

  • Large-scale international data on atopic dermatitis (AD) burden across pediatric age groups is limited.
  • Characterizing the impact of AD in children and adolescents is crucial for understanding disease prevalence and management.

Purpose of the Study:

  • To characterize the burden of atopic dermatitis (AD) in pediatric patients stratified by disease severity.
  • To evaluate the impact of AD on symptoms, quality of life, and daily functioning in children and adolescents.

Main Methods:

  • A cross-sectional, web-based survey was conducted in 18 countries involving pediatric patients (6 months to <18 years) diagnosed with AD.
  • Disease severity was assessed using validated measures (Patient-Oriented Eczema Measure, Patient Global Assessment).
  • Outcomes included itch, skin pain, sleep disturbance, health-related quality of life (HRQoL), school absenteeism, and atopic comorbidities.

Main Results:

  • The study surveyed 7,465 pediatric patients with AD across different age bands.
  • Patients with moderate-to-severe AD reported significantly higher levels of itch, skin pain, and sleep problems compared to those with mild AD.
  • Moderate-to-severe AD was associated with impaired HRQoL and increased school absenteeism; severe AD presented a greater burden than moderate AD.
  • Over 92% of all respondents had at least one atopic comorbidity.

Conclusions:

  • Atopic dermatitis imposes a substantial burden on pediatric patients, particularly those with moderate-to-severe disease.
  • Findings underscore the need for comprehensive assessments that evaluate the functional and daily life impact of AD in children and adolescents.
  • Effective management strategies should address the multifaceted burden of AD beyond just skin symptoms.
Abstract

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