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Copper neurotoxicity: Induction of cognitive dysfunction: A review
1Department of Anesthesiology, Affiliated Hospital of North Sichuan Medical College, Nanchong, China.
Copper-induced cognitive dysfunction is linked to cuproptosis, a novel cell death pathway. Understanding this mechanism offers new therapeutic targets for cognitive decline in various diseases.
Area of Science:
- Neuroscience
- Cell Biology
- Pathology
Background:
- Cognitive dysfunction is prevalent in aging, diseases, anesthesia, surgery, and chemotherapy.
- Mechanisms include neuroinflammation, oxidative stress, mitochondrial dysfunction, and impaired synaptic plasticity.
- Copper's role in cognitive decline is increasingly recognized, particularly through cuproptosis.
Conclusions:
- Cuproptosis presents a novel mechanism contributing to cognitive dysfunction.
- Targeting copper metabolism and cuproptosis may offer new therapeutic strategies.
- Further research is needed to elucidate the precise mechanisms of cuproptosis in cognitive decline.
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