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The differentiation courses of the Tfh cells: a new perspective on autoimmune disease pathogenesis and treatment

Qingya Yang1, Fang Zhang2,3, Hongyi Chen2,3

  • 1Division of Rheumatology, People's Hospital of Mianzhu, Mianzhu, Sichuan, 618200, China.

Bioscience Reports
|December 5, 2023
PubMed

The follicular helper T cells are derived from CD4+T cells, promoting the formation of germinal centers and assisting B cells to produce antibodies. This review describes the differentiation process of Tfh cells from the perspectives of the initiation, maturation, migration, efficacy, and subset classification of Tfh cells, and correlates it with autoimmune disease, to provide information for researchers to fully understand Tfh cells and provide further research ideas to manage immune-related diseases.

Keywords:
autoimmune diseasedifferentiation coursesfollicular helper T cells

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