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Multiple Hypointense Vessels are Associated with Cognitive Impairment in Patients with Single Subcortical Infarction

Tang Yang1, Pengfei Peng2, Shuai Jiang1

  • 1Department of Neurology, West China Hospital, Sichuan University, No. 37, Guo Xue Xiang, Chengdu, 610041, China.

Translational Stroke Research
|December 5, 2023
PubMed

Insights

Multiple hypointense vessels, including deep medullary veins (DMVs) and cortical veins (CVs), are linked to cognitive function in single subcortical infarction (SSI) patients. These associations were stronger in branch atheromatous disease (BAD) related SSI.

Area of Science:

  • Neurology
  • Neuroimaging
  • Cognitive Science

Background:

  • Single subcortical infarction (SSI) can lead to cognitive impairment.
  • The role of cerebral venous abnormalities in cognitive decline post-SSI is not fully understood.
  • Understanding these relationships can inform targeted interventions for post-stroke cognitive dysfunction.

Purpose of the Study:

  • To investigate the association between multiple hypointense vessels (DMVs and CVs) and cognitive function in acute SSI patients.
  • To explore the influence of different etiological mechanisms of SSI (BAD vs. CSVD) on this relationship.
  • To provide insights into the pathophysiology of cognitive impairment following SSI.

Main Methods:

  • Assessed deep medullary veins (DMVs) and cortical veins (CVs) scores in 103 acute SSI patients using whole-brain vessel-wall MRI.
  • Evaluated cognitive function using Montreal Cognitive Assessment (MoCA), Shape Trail Test (STT), and Stroop Color and Word Test (SCWT).
  • Dichotomized SSI etiology into branch atheromatous disease (BAD) and cerebral small vessel disease (CSVD)-related SSI.

Main Results:

  • Higher DMVs scores correlated with poorer performance on STT-B and STT-B-1 min in SSI patients.
  • Higher CVs scores correlated with poorer performance on STT-A in SSI patients.
  • The associations between DMVs/CVs scores and cognitive function were significantly more pronounced in BAD patients compared to CSVD-related SSI.

Conclusions:

  • Multiple hypointense vessels, specifically DMVs and CVs, are associated with multi-domain cognitive impairment in SSI patients.
  • The etiological mechanism of SSI, particularly BAD, influences the strength of these associations.
  • Further research into venous alterations is crucial for understanding and managing post-stroke cognitive impairment.

Keywords:
Cognitive ImpairmentCortical VeinsDeep Medullary VeinsSubcortical InfarctionVessel-wall Magnetic Resonance Imaging

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