An Extrusion Strategy for On-Demand SF₅Cl Gas Generation from a Commercial Disulfide

Herein we report a novel methodology for the ex situ generation of SF₅Cl by employing 4,4'-dipyridyl disulfide as a safe commercial reagent, obviating the need for lecture bottles. The method is applicable to certain SF₅Cl-involving transformations by using a two-chamber reactor. Moreover, easily applying SF₅Cl in different solvents is rendered feasible, while avoiding the use of glovebox techniques. This report also suggests ¹H-¹⁹F HOESY as a simple and fast stereochemistry indication for chloropentafluorosulfanylated olefins.