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Related Experiment Video

Updated: Jul 9, 2025

Microbiota Analysis Using Two-step PCR and Next-generation 16S rRNA Gene Sequencing
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Interactive Association Between Gut Microbiota and Thyroid Cancer.

Tianzhichao Hou1,2, Qi Wang1,2, Huajie Dai1,2

  • 1Department of Endocrine and Metabolic Diseases, Shanghai Institute of Endocrine and Metabolic Diseases, Ruijin Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai 200025, China.

Endocrinology
|December 5, 2023
PubMed
Summary
This summary is machine-generated.

This study investigated gut microbiota and thyroid cancer, finding specific bacteria and metabolic pathways causally linked to cancer development. Further research is needed due to conflicting observational data.

Keywords:
Mendelian randomization analysiscausal relationshipgastrointestinal microbiomesystematic reviewthyroid neoplasms

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Area of Science:

  • Microbiology
  • Oncology
  • Genetics

Background:

  • The relationship between gut microbiota and thyroid cancer is not well understood.
  • Existing observational studies show conflicting results.

Approach:

  • Utilized bidirectional Mendelian randomization (MR) with large-scale genome-wide association studies.
  • Analyzed 211 microbiota taxa and 205 metabolism pathways for causal links to thyroid cancer.
  • Included a systematic review of observational studies for comparison.

Key Points:

  • Eight gut taxa and 12 metabolism pathways showed causal effects on thyroid cancer.
  • Specific genera (e.g., RuminococcaceaeUCG004, Olsenella) and pathways (e.g., ketogluconate metabolism) were implicated.
  • Thyroid cancer also causally affected 3 taxa and 2 metabolism pathways, with Holdemanella genus noted.

Conclusions:

  • Findings suggest a role for host-microbiota interactions in thyroid cancer.
  • Discrepancies with observational studies highlight the need for more research.