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Clonal hematopoiesis of indeterminate potential: implications for the cardiologists

Edoardo Sciatti1, Emilia D'Elia1, Mauro Gori1

  • 1Cardiology Unit 1, ASST-Papa Giovanni XXIII.

Journal of Cardiovascular Medicine (Hagerstown, Md.)
|December 5, 2023
PubMed

Insights

Somatic gene mutations in bone marrow stem cells can lead to clonal hematopoiesis of indeterminate potential (CHIP), causing inflammation and increasing cardiovascular risks like heart attack and stroke.

Area of Science:

  • Hematology
  • Cardiology
  • Immunology

Background:

  • Myeloproliferative neoplasms (MPNs) share somatic gene mutations in bone marrow stem cells, linked to cardiovascular complications via inflammation.
  • Similar mutations are now identified in cardiovascular disease patients without MPNs, defining clonal hematopoiesis of indeterminate potential (CHIP).

Approach:

  • This review examines the link between clonal hematopoiesis, chronic inflammation, and cardiovascular diseases.
  • Focuses on a practical approach to enhance clinical practice and identify knowledge gaps.

Key Points:

  • CHIP, an age-related condition, is associated with increased risks of myocardial infarction, stroke, and heart failure.
  • The underlying genetic mutations in CHIP drive systemic chronic inflammation, contributing to cardiovascular events.
  • Understanding this link is crucial for managing patients with CHIP and cardiovascular disease.

Conclusions:

  • Clonal hematopoiesis is an emerging driver of cardiovascular disease through inflammatory pathways.
  • Further research is needed to develop targeted therapies and improve clinical management for CHIP patients.
  • Bridging hematology and cardiology is essential for addressing the unmet needs in this field.

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