A Massive Case of Cutaneous Diffuse Large B-Cell Lymphoma

Area of Science:

• Oncology
• Dermatology
• Hematology

Background:

• Diffuse large B-cell lymphoma (DLCL) is the most prevalent form of non-Hodgkin lymphoma.
• Extranodal DLCL occurs in about 40% of cases, but involvement of skin and muscle is uncommon.
• Typical cutaneous manifestations include plaques, papules, nodules, or ulcers.

Observation:

• A patient presented with a large exophytic mass affecting the skin, soft tissue, and muscle.
• The initial clinical diagnosis was baso-squamous carcinoma.
• The mass was ultimately identified as DLCL upon further investigation.

Findings:

• The case demonstrates a rare presentation of DLCL involving extensive skin, soft tissue, and muscle.
• The tumor mimicked a primary skin cancer, such as baso-squamous carcinoma.
• Diagnosis was confirmed through histopathological examination.

Implications:

• This case underscores the importance of considering DLCL in the differential diagnosis of unusual cutaneous and soft tissue masses.
• It highlights that DLCL can present with a large exophytic morphology, challenging initial diagnostic assumptions.
• The successful treatment solely with chemotherapy suggests its potential efficacy in such rare presentations.