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The neurovascular unit-on-a-chip: modeling ischemic stroke to stem cell therapy

Seonghun Kim1, Minjun Kim2, Gerald A Grant1,2,3,4

  • 1Department of Neurosurgery, Duke University School of Medicine, Durham, NC, USA.

Neural Regeneration Research
|December 5, 2023
PubMed
Abstract

No abstract available in PubMed .

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Ischemic Stroke ll: Pathophysiology01:15

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An ischemic stroke occurs when a cerebral blood vessel becomes obstructed, most often by a thrombus or embolus, interrupting the delivery of oxygen and glucose to brain tissue. Because neurons rely on continuous aerobic metabolism, energy failure begins within minutes of reduced perfusion. The region receiving the least blood flow becomes the infarct core, an area of irreversible cellular death. Surrounding this core lies the penumbra, a zone of hypoperfused but still viable tissue that is...

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