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Updated: Jul 9, 2025

Visualization of SARS-CoV-2 using Immuno RNA-Fluorescence In Situ Hybridization
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Expression of TRIM56 gene in SARS-CoV-2 variants and its relationship with progression of COVID-19

Rezvan Tavakoli1, Pooneh Rahimi1,2, Mojtaba Hamidi-Fard1,2

  • 1Hepatitis & AIDS Department, Pasteur Institute of Iran, Tehran, Iran.

Future Virology
|December 5, 2023
PubMed
Abstract

Insights

Lower TRIM56 gene expression correlates with severe COVID-19, particularly with the Delta variant. This finding highlights TRIM56's potential role in disease severity across different SARS-CoV-2 variants.

Area of Science:

  • Immunology
  • Virology
  • Genetics

Background:

  • Severe COVID-19 is a global health concern.
  • Understanding genetic factors influencing disease severity is crucial.
  • The role of TRIM56 in SARS-CoV-2 infection requires further investigation.

Purpose of the Study:

  • To investigate the correlation between TRIM56 gene expression and COVID-19 severity.
  • To compare TRIM56 expression across different SARS-CoV-2 variants (Alpha, Delta, Omicron BA.5).

Main Methods:

  • Quantitative real-time PCR (qPCR) was used to measure TRIM56 mRNA levels.
  • The study included 330 COVID-19 patients (142 severe, 188 mild) and 160 healthy controls.

Main Results:

  • TRIM56 mRNA expression was significantly lower in both severe and mild COVID-19 patients compared to healthy individuals.
  • A high reduction in TRIM56 mRNA expression was observed in patients infected with the Delta variant.
  • A low reduction in TRIM56 mRNA expression was observed in patients infected with the Omicron BA.5 variant.

Conclusions:

  • Differential TRIM56 expression is associated with COVID-19 severity.
  • TRIM56 may play a role in the varying severity observed with different SARS-CoV-2 variants.
  • Further research is warranted to elucidate the precise mechanisms by which TRIM proteins influence COVID-19 outcomes.
Keywords:
C-reactive proteinSARS-CoV-2coronavirus disease 2019mild infectionsevere infectiontripartite motif containing 56viral RNA load

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