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Red cell exchange for rapid leukoreduction in adults with hyperleukocytosis and leukostasis

Ethan A Mack1, Meaghan C Dougher1, Ashley M Ginda1

  • 1Division of Transfusion Medicine and Therapeutic Pathology, Department of Pathology and Laboratory Medicine, Hospital of the University of Pennsylvania, Philadelphia, PA.

Blood
|December 5, 2023
PubMed

We show that red cell exchange (RCE) treats hyperleukocytosis in acute leukemia. RCE provided similar leukoreduction to standard therapeutic leukoreduction and could be superior in patients with severe anemia or monocytic leukemias or when requiring rapid treatment.

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