ABUS tumor segmentation via decouple contrastive knowledge distillation

Objective.In recent years, deep learning-based methods have become the mainstream for medical image segmentation. Accurate segmentation of automated breast ultrasound (ABUS) tumor plays an essential role in computer-aided diagnosis. Existing deep learning models typically require a large number of computations and parameters.Approach. Aiming at this problem, we propose a novel knowledge distillation method for ABUS tumor segmentation. The tumor or non-tumor regions from different cases tend to have similar representations in the feature space. Based on this, we propose to decouple features into positive (tumor) and negative (non-tumor) pairs and design a decoupled contrastive learning method. The contrastive loss is utilized to force the student network to mimic the tumor or non-tumor features of the teacher network. In addition, we designed a ranking loss function based on ranking the distance metric in the feature space to address the problem of hard-negative mining in medical image segmentation.Main results. The effectiveness of our knowledge distillation method is evaluated on the private ABUS dataset and a public hippocampus dataset. The experimental results demonstrate that our proposed method achieves state-of-the-art performance in ABUS tumor segmentation. Notably, after distilling knowledge from the teacher network (3D U-Net), the Dice similarity coefficient (DSC) of the student network (small 3D U-Net) is improved by 7%. Moreover, the DSC of the student network (3D HR-Net) reaches 0.780, which is very close to that of the teacher network, while their parameters are only 6.8% and 12.1% of 3D U-Net, respectively.Significance. This research introduces a novel knowledge distillation method for ABUS tumor segmentation, significantly reducing computational demands while achieving state-of-the-art performance. The method promises enhanced accuracy and feasibility for computer-aided diagnosis in diverse imaging scenarios.