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ER chaperones use a protein folding and quality control glyco-code

Kevin P Guay1, Haiping Ke2, Nathan P Canniff1

  • 1Department of Biochemistry and Molecular Biology, University of Massachusetts Amherst, Amherst, MA, USA; Program in Molecular and Cellular Biology, University of Massachusetts Amherst, Amherst, MA, USA.

Molecular Cell
|December 5, 2023
PubMed
Summary

The glyco-code, or N-glycan features, guides protein folding and quality control in the endoplasmic reticulum. Specific glycan patterns dictate chaperone interactions for serpins like alpha-1 antitrypsin and antithrombin III maturation.

Keywords:
ER-mediated protein quality controlERQCN-linked glycosylationendoplasmic reticulumlectin chaperonesprotein foldingprotein homeostasisprotein maturationproteostasisserpins

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