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Mutations, Bottlenecks, and Clonal Sweeps: How Environmental Carcinogens and Genomic Changes Shape Clonal Evolution

Melissa Q Reeves1,2, Allan Balmain3

  • 1Huntsman Cancer Institute, University of Utah, Salt Lake City, Utah 84112, USA Melissa.Reeves@hci.utah.edu Allan.Balmain@ucsf.edu.

Cold Spring Harbor Perspectives in Medicine
|December 5, 2023
PubMed
Summary

Cancer progression involves genomic evolution driven by carcinogens or genetic events. Mouse models reveal distinct clonal dynamics in tumors, offering insights into cancer evolution in mice and humans.

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