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Elevated luteinizing hormone receptor signaling or selenium treatment leads to comparable changes in adrenal

Jaroslaw Wieczorek1, Piotr Pawlicki2, Marta Zarzycka2

  • 1University Centre of Veterinary Medicine JU-UA, University of Agriculture in Krakow, Mickiewicza 24/28, 30-059, Krakow, Poland.

Protoplasma
|December 5, 2023
PubMed

Insights

Luteinizing hormone (LH) signaling and selenium (Se2+) impact adrenal androgen signaling differently. LH increased testosterone and zinc, while Se2+ decreased them, affecting androgen receptor (AR) and ZIP9 expression.

Area of Science:

  • Endocrinology
  • Adrenal Physiology
  • Molecular Biology

Background:

  • Adrenal androgen production and signaling are not fully understood.
  • Appropriate animal models for adrenal research are needed.
  • Investigating novel signaling pathways in adrenal cortex is crucial.

Purpose of the Study:

  • To evaluate the effect of luteinizing hormone (LH) signaling on adrenal androgen signaling.
  • To assess the impact of selenium (Se2+) exposure on adrenal androgen signaling.
  • To explore the roles of the canonical androgen receptor (AR) and membrane androgen receptor ZIP9.

Main Methods:

  • Utilized transgenic mice (KiLHRD582G) with elevated LH receptor signaling.
  • Employed ex vivo rabbit adrenal cortex cultures exposed to Se2+.
  • Performed histological, morphometric, Western blot, testosterone, and zinc level analyses.

Main Results:

  • Cell hypertrophy observed in both KiLHRD582G mice and Se2+-treated rabbits.
  • AR expression decreased in both models; ZIP9 expression varied.
  • LH signaling increased adrenal testosterone and zinc; Se2+ decreased them.

Conclusions:

  • LH and Se2+ differentially regulate adrenal androgen signaling pathways.
  • AR and ZIP9 are key players in adrenal response to LH and Se2+.
  • These findings contribute to understanding adrenal physiology and disease models.
Keywords:
AdrenalsAndrogen receptorAndrogensLuteinizing hormone receptorSeleniumzinc transporter

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