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Updated: Jul 9, 2025
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Association Between Stroke Severity and Serum Troponin in Acute Stroke
Andrea M Kuczynski1, Grace Rzyczniak2, Gee Hung Leo Cheong3
1Division of Neurology, Department of Medicine, University of Toronto, Toronto, ON, Canada.
Abstract:
Serum troponin is often elevated in patients with acute stroke and its mechanism is unknown. In a retrospective single-center cohort study, we evaluated the association between stroke severity and serum troponin in 187 patients with acute stroke using multivariable modified Poisson models. A one-point increase in the National Institutes of Health Stroke Scale (measure of stroke severity) was associated with a marginally higher serum troponin level in adjusted models (aIRR 1.03; 1.01-1.05, P = 0.001). The modest, yet potentially independent, association between stroke severity and serum troponins could suggest a neurogenic basis for a cardiac injury in patients with acute stroke.
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