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Updated: Jul 9, 2025

Author Spotlight: Exploring the Role of Inflammation in the Co-occurrence of Primary Sjogren's Syndrome and Lung Adenocarcinoma
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Author Spotlight: Exploring the Role of Inflammation in the Co-occurrence of Primary Sjogren's Syndrome and Lung Adenocarcinoma

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Exploring the expression of SNHG1 and its effect on the PI3K-AKT axis in nasopharyngeal cancer

Yong Yang1,2, Yan-Ping Yang1, Mei-Ling Yi2

  • 1Department of Otolaryngology-Head and Neck Surgery, The First Affiliated Hospital of Guangxi Medical University, Nanning, China.

Neoplasma
|December 6, 2023
PubMed

Insights

Small nucleolar RNA host gene 1 (SNHG1) is overexpressed in nasopharyngeal carcinoma (NPC), suggesting its potential as a diagnostic biomarker. SNHG1 may influence NPC progression via the PI3K-AKT signaling pathway.

Area of Science:

  • Oncology
  • Molecular Biology
  • Biochemistry

Background:

  • Nasopharyngeal carcinoma (NPC) treatments have limitations due to side effects.
  • Small nucleolar RNA host genes (SNHGs) are emerging as key players in various cancers.
  • Limited research exists on the role of SNHG1 in NPC pathogenesis.

Purpose of the Study:

  • To investigate the diagnostic potential of SNHG1 in NPC.
  • To explore the signaling pathways implicated in SNHG1-mediated NPC progression.
  • To validate SNHG1 expression and pathway involvement in NPC tissues.

Main Methods:

  • Bioinformatic analysis of SNHG1 expression and associated pathways in NPC and head and neck squamous cell carcinoma (HNSC).
  • Reverse transcription quantitative polymerase chain reaction (RT-qPCR) to confirm SNHG1 expression in NPC tissues.
  • Immunohistochemistry to detect the expression of key proteins in the PI3K-AKT signaling pathway (PI3K, AKT, EGFR) and CASP3.

Main Results:

  • SNHG1 was found to be significantly overexpressed in both HNSC and NPC tissues.
  • RT-qPCR confirmed the significant overexpression of SNHG1 in NPC tissues.
  • Bioinformatic and experimental results suggest SNHG1's involvement in NPC through the PI3K-AKT signaling pathway, with positive expression of PI3K, AKT, EGFR, and weak positive expression of CASP3 in NPC tissues.

Conclusions:

  • SNHG1 is a potential diagnostic biomarker for NPC.
  • SNHG1 may contribute to NPC development and progression via the PI3K-AKT signaling pathway.

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