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Updated: Jul 9, 2025

Elucidating the Metabolism of 2,4-Dibromophenol in Plants
Published on: February 10, 2023
Lipid metabolism analysis providing insights into nonylphenol multi-toxicity mechanism
Fuwen Liu1, Xue Cao2, Lei Zhou3
1School of Chemical and Environmental Engineering, Shanghai Institute of Technology, Shanghai 201418, China.
Abstract:
Nonylphenol (NP), a widely recognized endocrine disruptor, exhibits lipophobic properties that drive its accumulation in adipose tissue, leading to various physiological disruptions. Using Caenorhabditis elegans, this study investigated the effects of NP exposure on lipid homeostasis and physiological indicators. NP exposure increased lipid storage, hindered reproduction and growth, and altered phospholipid composition. Transcriptional analysis revealed NP's promotion of lipogenesis and inhibition of lipolysis. Metabolites related to lipid metabolism like citrate, amino acids, and neurotransmitters, along with lipids, collectively influenced physiological processes. This work elucidates the complex link between lipid metabolism disturbances and NP-induced physiological disruptions, enhancing our understanding of NP's multifaceted toxicity.

