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Antiasthma Drugs: Mast Cell Stabilizers and Anti-IgE Drugs

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Asthma is a chronic respiratory condition for which new therapeutic avenues, including anti-inflammatory drugs like mast cell stabilizers and anti-IgE treatments, continue to be developed.
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Asthma: Pathogenesis and Management

Asthma: Pathogenesis and Management

Asthma is a chronic pulmonary condition involving inflammation of the airways, hyper-reactivity, and reversible obstruction of the airways. This condition can significantly impact a person's quality of life, making breathing difficult and leading to distressing symptoms.
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Related Experiment Video

Updated: Jul 9, 2025

Bronchial Thermoplasty: A Novel Therapeutic Approach to Severe Asthma

Bronchial Thermoplasty: A Novel Therapeutic Approach to Severe Asthma

Published on: November 4, 2010

[Unmet Needs in Severe Allergic Asthma].

Julio Delgado¹, Ana Navarro¹, Francisco Javier Álvarez-Gutiérrez²

¹Unidad de Gestión Clínica, Alergología, Hospital Virgen Macarena, Sevilla, España.

Open Respiratory Archives

|December 6, 2023

Summary

Severe allergic asthma impacts many globally. This review offers expert recommendations and identifies unmet needs for improved management, especially for patients unresponsive to current treatments.

Keywords:

Allergens Biomarkers IgE Omalizumab Severe allergic asthma Treatments

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Last Updated: Jul 9, 2025

Bronchial Thermoplasty: A Novel Therapeutic Approach to Severe Asthma

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Published on: November 4, 2010

Murine Model of Allergen Induced Asthma

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Published on: May 14, 2012

Symptom Assessment of Patients with Allergic Rhinitis Using an Allergen Exposure Chamber

Symptom Assessment of Patients with Allergic Rhinitis Using an Allergen Exposure Chamber

Published on: March 3, 2023

Area of Science:

Immunology
Pulmonology
Allergy

Context:

Severe asthma, particularly allergic asthma, affects 3%-10% of the global population.
Allergic asthma is driven by type 2 inflammation with immunoglobulin E (IgE) as a key mediator.
Despite advances in precision medicine and biological therapies, a significant patient subset remains refractory to treatment.

Purpose:

To review and evaluate evidence on severe allergic asthma pathophysiology, phenotypes, and IgE's role.
To assess allergen identification, diagnostics, and current treatment strategies, focusing on biologics.
To develop expert recommendations for improved management and identify unmet needs via Delphi consensus.

Summary:

This expert review synthesizes current knowledge on severe allergic asthma, emphasizing the role of IgE and type 2 inflammation.
It critically examines diagnostic challenges and evaluates available treatments, including targeted biological therapies.
Recommendations for enhanced disease management and identification of research gaps were established through a Delphi consensus process.

Impact:

Provides clinicians with evidence-based recommendations for managing severe allergic asthma.
Highlights critical unmet needs in severe allergic asthma treatment, guiding future research and therapeutic development.
Aims to improve clinical remission rates and patient outcomes in severe allergic asthma through optimized management strategies.