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Medication Related-Problems and Associated Factors Among Patients with Hypertension at a Tertiary Care Hospital in
Aster Wakjira Garedow1, Mekonnen Damessa Mamo1, Gorfineh Teshome Tesfaye2
1Jimma University, School of Pharmacy, Jimma, Ethiopia.
Insights
Medication related problems are common in hypertension patients, affecting over two-thirds. Alcoholism, advanced hypertension, comorbidities, and polypharmacy predict these issues, necessitating collaborative care.
Area of Science:
- Pharmacology and Clinical Pharmacy
- Public Health
- Cardiology
Background:
- Hypertension impacts over 1.4 billion globally, projected to reach 1.6 billion by 2025.
- Medication-related problems (MRPs) are prevalent and critical in hypertension management, leading to adverse outcomes.
- These problems contribute to mortality, complications, extended hospital stays, reduced quality of life, and increased healthcare costs.
Purpose of the Study:
- To determine the prevalence of medication-related problems (MRPs) among hypertension patients.
- To identify predictors of MRPs in hypertensive patients undergoing chronic follow-up.
- To inform interventions aimed at improving medication management in hypertension.
Main Methods:
- A prospective interventional study was conducted at Jimma Medical Center from November 2021 to June 2022.
- Medication-related problems were identified using the Pharmaceutical Care Network Europe (PCNE) drug classification tool v9.0.
- Binary logistic regression analysis identified independent predictors of MRPs, with statistical significance set at P < 0.05.
Main Results:
- Out of 384 hypertension patients, 60.15% experienced at least one MRP, with 483 MRPs identified in total.
- Treatment effectiveness problems were the most common (55.48%).
- Independent predictors included alcoholism (AOR=3.15), stage II hypertension (AOR=2.77), comorbidity (AOR=2.88), and polypharmacy (AOR=3.07).
Conclusions:
- A high prevalence of medication-related problems exists among hypertensive patients.
- Alcoholism, stage II hypertension, comorbidities, and polypharmacy are significant predictors of MRPs.
- Collaborative efforts among clinical pharmacists, physicians, and healthcare professionals are crucial for addressing these medication-related problems.
Background:
Hypertension affects more than 1.4 billion people worldwide currently, with that number anticipated to climb to 1.6 billion by 2025 with high mortality and morbidity effects. Medication related problems in cardiovascular disease patients, especially among hypertension patients were found to be high and a critical problem which is associated with high mortality, complication, prolonged hospital stay, compromised quality of life and increase health care cost.
Objective:
To determine medication related problems and its predictors among hypertension patients on chronic follow-up at Jimma Medical Center.
Methods:
A prospective interventional study was conducted among hypertension patients from November 28, 2021 to June 30, 2022 at Jimma Medical Center. Medication related problems were classified and identified based on Pharmaceutical care network Europe drug classification tool version 9.0. Interventions were done through discussion with individual prescriber and patients. Consecutive sampling technique was used. Binary Logistic regression was used to identify independent predictors of medication related problems. Variables having P-values < 0.05 were considered statistically significant.
Results:
Among 384 hypertension patients included in the study, 219 (57.1%) were male. The mean (SD) age was 49.06+17.79. Two thirds of study participants had at least one medication related problem. A total of 483 MRPs were identified among 231 (60.15%) patients. Treatment effectiveness related problem (55.48%) was the most common observed medication related problems. Alcoholism (AOR; 3.15, 95% CI [1.46-7.23]), stage II hypertension (AOR=2.77, 95% CI= [3.53-4.66]); comorbidity (AOR=2.88, 95% CI= [1.47-5.66]) and polypharmacy (AOR=3.07, 95% CI= [1.57-5.99]) were the independent predictors of medication related problems.
Conclusion:
The prevalence of medication related problems was high among hypertensive patients. Alcoholism, stage II hypertension, comorbidity and poly-pharmacy were the predictors of medication related problems. Therefore, to overcome the problems, clinical pharmacists, physicians and other health care professionals have to work in collaboration.
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