Related Experiment Video
Updated: Jul 9, 2025

10:39
3D-Neuronavigation In Vivo Through a Patient's Brain During a Spontaneous Migraine Headache
Published on: June 2, 2014
18.3K
Frontal site surgery for chronic migraine therapy
Giorgio Raposio1, Andrea Antonini2, Alessandro Gualdi3
1Plastic Surgery Chair, Department of Surgical Sciences and Integrated Diagnostics (DISC), University of Genova, Italy. giorgioraposio@hotmail.it.
Acta Bio-Medica : Atenei Parmensis
|December 6, 2023
Summary
Surgical treatment involving neurolysis of the supraorbital and supratrochlear nerves effectively treats chronic frontal migraines. This procedure offers significant symptom reduction and a low complication rate for drug-resistant cases.
Area of Science:
- Neurology
- Neurosurgery
Background:
- Chronic inflammation of cranial nerves, specifically the supraorbital and supratrochlear nerves, is theorized to cause frontal migraines.
- Surgical intervention, including complete neurolysis of these nerves, is a treatment option for intractable cases.
Purpose of the Study:
- To evaluate the efficacy and safety of surgical neurolysis for chronic, drug-resistant frontal migraines.
Main Methods:
- A cohort of 98 patients with drug-resistant frontal migraines underwent surgical neurolysis between 2011 and 2022.
- Patient outcomes were assessed using a specific questionnaire at three months and one year post-surgery.
Main Results:
- An 87% success rate (≥50% reduction in monthly migraine attacks) was observed at three months, with 32% achieving complete recovery.
- These positive outcomes were sustained at the one-year follow-up.
- Complications, primarily transient paresthesias and dysesthesias, were infrequent and resolved spontaneously.
Conclusions:
- Surgical neurolysis of the supraorbital and supratrochlear nerves provides significant therapeutic benefits for chronic frontal migraines.
- The procedure demonstrates a favorable safety profile with a low incidence of manageable complications.

