Single Nucleotide Polymorphisms Associated with Prostate Cancer Progression: A Systematic Review
Daniel Felipe Mendivelso González1, Santiago Andrés Sánchez Villalobos1, Andrea Estefanía Ramos1
1Cancer Biology Research Group, Instituto Nacional de Cancerología, Bogotá, Colombia.
Cancer Investigation
|December 6, 2023
Summary
Single nucleotide polymorphisms (SNPs) show promise as biomarkers for prostate cancer (PCa) progression. This review identified numerous SNPs significantly associated with higher or lower risks, aiding in PCa management.
Area of Science:
- Genetics and Genomics
- Oncology
- Biomarker Discovery
Background:
- Prostate cancer (PCa) requires improved biomarkers for accurate classification and clinical management.
- Current methods for predicting PCa progression need enhancement.
- Identifying novel progression markers is crucial for patient outcomes.
Conclusions:
- Single nucleotide polymorphisms (SNPs) represent potential biomarkers for prostate cancer progression.
- Identified SNPs may have functional roles in PCa development and progression.
- Further research is needed to validate findings, particularly across diverse populations, as most variants were identified in limited cohorts.
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01:11Genome-wide Association Studies-GWAS
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