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Cancer management in terms of precision oncology
Shrikant B Mali1, Sachinkumar Dahivelkar1
1Mahatma Gandhi Vidya Mandir's Dental College and Hospital Nashik, India.
Abstract:
Cancer processes have been studied for over a century, but clinical care still relies on morphological and histological approaches. Modern diagnostic and therapy options include molecular characterisation of abnormal genes, cell surface indicators, hormonal/endocrine mediators, and signaling pathways. Targeted medicines, synthetic lethal targeting, and immune checkpoint inhibitors have spurred hope for molecular targets in cancer management. Precision medicine programs aim to transform population-based research into biomarker-driven clinical trials, but disparities in access to genetic profiling and inexpensive precision oncology drugs must be addressed to ensure cost-effective therapies are available to all patients.
Insights
Cancer care is advancing beyond traditional methods to molecular diagnostics and targeted therapies. Addressing access disparities is crucial for equitable, cost-effective precision oncology for all patients.
Area of Science:
- Oncology
- Molecular Biology
- Genetics
Background:
- Clinical cancer care historically relies on morphological and histological assessments.
- Modern approaches incorporate molecular characterization of genes, cell surface markers, and signaling pathways.
Discussion:
- Targeted medicines, synthetic lethality, and immune checkpoint inhibitors represent significant advancements in cancer management.
- Precision medicine aims to translate research into biomarker-driven clinical trials.
Key Insights:
- Molecular profiling offers new diagnostic and therapeutic avenues in oncology.
- Targeted therapies and immunotherapies are transforming cancer treatment paradigms.
Outlook:
- Ensuring equitable access to genetic profiling and affordable precision oncology drugs is essential.
- Addressing disparities is key to realizing cost-effective cancer therapies for all patients.
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