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Fructose sweetens the adipocyte-T cell alliance against tumors
1Department of Immunology, St. Jude Children's Research Hospital, Memphis, TN 38105, USA.
Cell Metabolism
|December 6, 2023
Abstract:
Dietary fructose is implicated in tumorigenesis, but whether dietary fructose regulates antitumor immunity remains elusive. In this issue of Cell Metabolism, Zhang et al. show that dietary fructose promotes adipocyte-derived leptin production, which attenuates terminal exhaustion programming and boosts the effector function of CD8+ T cells for improved tumor control.

