Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Structure and Function of Platelets01:18

Structure and Function of Platelets

1.2K
The cell fragments known as platelets are disc-shaped, with an average diameter of about 3 μm and a thickness of roughly 1 μm. They play a crucial role in the body's vascular clotting system, which also involves plasma proteins, blood cells, and blood vessel tissues.
Platelets are continually replenished, circulating in the bloodstream for 9-12 days before being removed by phagocytes, primarily in the spleen. A microliter of circulating blood contains between 150,000 and 450,000...
1.2K
Formation of the Platelet Plug01:22

Formation of the Platelet Plug

6.4K
The platelet phase, the second stage of hemostasis, commences around 15-20 seconds after an injury. It follows and overlaps with the vascular phase, during which blood vessels constrict to minimize blood loss.
As the injured blood vessel contracts, endothelial cells undergo contraction, revealing collagen fibers in the basement membrane and underlying connective tissue. Furthermore, the plasma membrane of endothelial cells becomes adhesive, preparing the site for platelet adhesion. Platelets...
6.4K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

PM2.5 as a driver of human health disorders: insights from the regulated cell death pathways.

Military Medical Research·2026
Same author

Retraction notice to "Interleukin-6 in SARS-CoV-2 induced disease: Interactions and therapeutic applications" [Biomedicine & Pharmacotherapy 145 (2022) 112419].

Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie·2026
Same author

Retraction notice to "Gene regulation by antisense transcription: A focus on neurological and cancer diseases" [Biomedicine & Pharmacotherapy 145 (2022) 112265].

Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie·2026
Same author

Retraction notice to "An update on the role of miR-124 in the pathogenesis of human disorders" [Biomedicine & Pharmacotherapy 135 (2021) 111198].

Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie·2026
Same author

Corrigendum to "Oleuropein reduces LPS-induced inflammation via stimulating M2 macrophage polarization" [Biomed. Pharmacother. 163 (2023) 114857].

Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie·2026
Same author

Regulatory T Cell Metabolism in Cancer.

Immunology·2025
Same journal

A follow-up cohort study on secondary findings in cancer predisposition genes from 20,205 Chinese individuals.

Clinica chimica acta; international journal of clinical chemistry·2026
Same journal

Chemometric profiling reveals selective circulating bile acid remodeling in Alzheimer's disease.

Clinica chimica acta; international journal of clinical chemistry·2026
Same journal

Serum sialic acid is independently associated with cerebrovascular atherosclerotic stenosis severity and total vascular burden: A retrospective cohort study.

Clinica chimica acta; international journal of clinical chemistry·2026
Same journal

Measurement of low-density lipoprotein cholesterol and other circulating lipids in Brazil: a systematic literature review.

Clinica chimica acta; international journal of clinical chemistry·2026
Same journal

Reference intervals for venous blood gas measurement in a healthy Chinese population.

Clinica chimica acta; international journal of clinical chemistry·2026
Same journal

Multiplex methylation marker analysis for ctDNA detection in liquid biopsies from anal cancer patients: an HPV-independent approach.

Clinica chimica acta; international journal of clinical chemistry·2026
See all related articles

Related Experiment Video

Updated: Jul 9, 2025

Megakaryocyte Differentiation and Platelet Formation from Human Cord Blood-derived CD34+ Cells
09:46

Megakaryocyte Differentiation and Platelet Formation from Human Cord Blood-derived CD34+ Cells

Published on: December 27, 2017

19.8K

Tumor-educated platelets.

Sajad Najafi1, Yahya Asemani2, Jamal Majidpoor3

  • 1Department of Medical Biotechnology, School of Advanced Technologies in Medicine, Shahid Beheshti University of Medical Sciences, Tehran, Iran; Cellular and Molecular Biology Research Center, Shahid Beheshti University of Medical Sciences, Tehran, Iran.

Clinica Chimica Acta; International Journal of Clinical Chemistry
|December 6, 2023
PubMed
Summary
This summary is machine-generated.

Platelets interact with cancer cells, becoming tumor-educated platelets (TEPs). These TEPs can serve as a blood-based biomarker for cancer prognosis and treatment monitoring, offering a minimally invasive approach.

Keywords:
BiomarkerCancerCirculating tumor cell (CTC)Liquid biopsyTumor educating platelet (TEP)

More Related Videos

A Uniform Shear Assay for Human Platelet and Cell Surface Receptors via Cone-plate Viscometry
04:32

A Uniform Shear Assay for Human Platelet and Cell Surface Receptors via Cone-plate Viscometry

Published on: June 5, 2019

7.7K
Procoagulant Platelet Characterization by Measuring Phosphatidylserine Exposure and Microvesicle Release from Human Purified Platelets
05:49

Procoagulant Platelet Characterization by Measuring Phosphatidylserine Exposure and Microvesicle Release from Human Purified Platelets

Published on: November 29, 2024

581

Related Experiment Videos

Last Updated: Jul 9, 2025

Megakaryocyte Differentiation and Platelet Formation from Human Cord Blood-derived CD34+ Cells
09:46

Megakaryocyte Differentiation and Platelet Formation from Human Cord Blood-derived CD34+ Cells

Published on: December 27, 2017

19.8K
A Uniform Shear Assay for Human Platelet and Cell Surface Receptors via Cone-plate Viscometry
04:32

A Uniform Shear Assay for Human Platelet and Cell Surface Receptors via Cone-plate Viscometry

Published on: June 5, 2019

7.7K
Procoagulant Platelet Characterization by Measuring Phosphatidylserine Exposure and Microvesicle Release from Human Purified Platelets
05:49

Procoagulant Platelet Characterization by Measuring Phosphatidylserine Exposure and Microvesicle Release from Human Purified Platelets

Published on: November 29, 2024

581

Area of Science:

  • Oncology
  • Hematology
  • Biomarker Discovery

Background:

  • Platelets, traditionally known for hemostasis and coagulation, are increasingly recognized for their role in cancer.
  • Platelets interact with cancer cells within the tumor microenvironment, undergoing significant molecular and functional alterations.
  • These altered platelets, termed tumor-educated platelets (TEPs), circulate systemically and influence tumor progression.

Purpose of the Study:

  • To provide an overview of tumor-educated platelets (TEPs).
  • To explore the potential of TEPs as a blood-based biomarker in cancer management.
  • To discuss the benefits and limitations of TEPs in the context of cancer prognosis and therapy.

Main Methods:

  • Review of existing literature on platelet-cancer cell interactions.
  • Analysis of molecular and functional changes in platelets within the tumor microenvironment.
  • Evaluation of TEPs as a component of liquid biopsies for cancer detection and monitoring.

Main Results:

  • Platelet-cancer cell interactions lead to 'education' of platelets, altering their molecular composition.
  • TEPs exhibit changes in adhesion molecules, glycoproteins, nucleic acids, and proteins.
  • TEPs play a role in promoting tumor growth and metastasis.

Conclusions:

  • Platelet status, particularly TEPs, represents a promising blood-based biomarker for cancer.
  • TEPs hold potential for predicting prognosis and therapeutic success in cancer patients.
  • TEPs are a valuable component of liquid biopsies, offering a minimally invasive approach to cancer management.