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Related Experiment Videos

Gastrointestinal obstruction associated with multiple-dose activated charcoal.

W A Watson, K F Cremer, J A Chapman

    The Journal of Emergency Medicine
    |January 1, 1986
    PubMed
    Summary

    Multiple doses of activated charcoal, used for carbamazepine intoxication, may cause gastrointestinal obstruction. This previously unreported adverse effect necessitates further evaluation of activated charcoal

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    Area of Science:

    • Toxicology
    • Gastroenterology
    • Emergency Medicine

    Background:

    • Activated charcoal is a common treatment for poisoning.
    • Carbamazepine overdose requires prompt management.

    Observation:

    • A patient with carbamazepine intoxication received large doses of activated charcoal and magnesium citrate.
    • The patient developed ileus and small-bowel obstruction.
    • Emesis occurred during activated charcoal administration.

    Findings:

    • Multiple doses of activated charcoal were associated with gastrointestinal obstruction.
    • This represents a potential, previously unreported adverse effect of activated charcoal therapy.
    • Ileus and small-bowel obstruction are serious complications.

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    Implications:

    • Clinicians should consider the risk of gastrointestinal obstruction with multiple doses of activated charcoal.
    • Further research is needed to determine the incidence of this adverse effect.
    • Optimal therapeutic regimens for activated charcoal require re-evaluation.