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Oxidative Amination of Aldehydes with Amines into α-Amino Ketones
Jie-Sheng Tian1, Shuang-Wen Xu1, Yan-Hang Bi1
1School of Chemistry and Chemical Engineering, Northwestern Polytechnical University (NPU), Xi'an 710072, China.
Abstract:
Oxidative amination for the installation of nitrogen functional molecules from nitrogen nucleophiles has always been a very challenging topic in organic synthesis. Here we report a novel conversion of different aldehydes with secondary amines for the synthesis of diversified α-amino ketones. This method can be achieved through oxidative rearrangement of an in situ-generated enamine intermediate promoted by commercially available sodium percarbonate. Furthermore, this one-pot process is also suitable for the functional modification of complex molecules.
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