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Published on: November 5, 2021
Clozapine Serum Concentrations Are Disrupted by SARS-CoV-2 Vaccinations
Xenia A K Kersting1, Nicoletta Momtahen1, Klaus Lieb1
1Department of Psychiatry and Psychotherapy, Johannes Gutenberg University Medical Center Mainz, Untere Zahlbacher Straße 8, 55131, Mainz, Germany.
Abstract:
This paper reports the case of a 27-year-old man with paranoid schizophrenia who was finally stabilized on clozapine medication. After vaccination against severe acute respiratory syndrome coronavirus 2, serum levels of clozapine increased. It is well established that immune responses can trigger cytokine cascades affecting drug metabolism, which, in the case of clozapine treatment, can lead to severe intoxication.
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