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Related Experiment Video

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Modified Algorithm Using Total Count for Calculating Myocardial Washout Rate in Single-Photon Emission Computerized

Hideyuki Miyauchi1, Ryohei Ono1, Takashi Iimori2

  • 1Department of Cardiovascular Medicine, Chiba University Graduate School of Medicine, Chiba, Japan.

Annals of Nuclear Cardiology
|December 7, 2023
PubMed
Summary

A new total count washout rate (TCWR) algorithm improves single-photon emission computerized tomography (SPECT) analysis for heart disease, especially with uneven radiotracer uptake. This method is suitable for various radiopharmaceuticals beyond iodine-123-β-methyl-p-iodophenylpentadecanoic acid (BMIPP).

Keywords:
CD36 deficiencyIodine-123-β-methyl-p-iodophenylpentadecanoic acid (BMIPP)Myocardial infarctionSingle-photon emission computerized tomography (SPECT)Triglyceride deposit cardiomyovasculopathy (TGCV)Washout rate

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Area of Science:

  • Cardiology
  • Nuclear Medicine
  • Medical Imaging Analysis

Background:

  • Arithmetic mean of washout rate (AMWR) is standard for SPECT polar map analysis.
  • AMWR is sensitive to uneven radiotracer uptake, potentially affecting accuracy.
  • A modified total count washout rate (TCWR) algorithm was developed to address this limitation.

Purpose of the Study:

  • To compare the accuracy of TCWR and AMWR in calculating washout rate (WR).
  • To evaluate the performance of TCWR and AMWR in different cardiovascular disease patient groups.
  • To assess the suitability of TCWR for handling heterogeneous radiotracer uptake in SPECT imaging.

Main Methods:

  • Calculated WR using both TCWR and AMWR for iodine-123-β-methyl-p-iodophenylpentadecanoic acid (BMIPP).
  • Compared WR values between TCWR and AMWR across patient groups: normal, CD36 deficiency, triglyceride deposit cardiomyovasculopathy (TGCV), TGCV with old myocardial infarction (OMI), and non-TGCV with OMI.
  • Statistical analysis was performed to determine significant differences in WR values between the two methods.

Main Results:

  • TCWR and AMWR showed no significant differences in WR for normal, CD36 deficiency, TGCV, and TGCV with OMI groups.
  • A significant difference was observed in the non-TGCV with OMI group, where AMWR yielded a lower WR than TCWR (p=0.0008).
  • TCWR demonstrated robustness in cases with heterogeneous radiotracer uptake, such as old myocardial infarction.

Conclusions:

  • TCWR is a reliable method for calculating WR from SPECT polar maps, particularly in the presence of heterogeneous radiotracer uptake.
  • TCWR offers an advantage over AMWR in specific conditions like non-TGCV with OMI.
  • TCWR has potential applications for other radiopharmaceuticals in studying heart disease pathophysiology.