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Updated: Jul 9, 2025
Isolation and Flow Cytometric Analysis of Immune Cells from the Ischemic Mouse Brain
Published on: February 12, 2016
Shared immune metabolic reprogramming between COVID-19 patients in the intensive care unit and ischemic stroke: a
Jie Li1, Fusheng Li1, Bin He2
1Department of Neurosurgery, Tongren Hospital, Shanghai Jiaotong University School of Medicine, Shanghai, China.
Introduction:
To investigate shared gene signatures between COVID-19 and ischemic stroke.
Methods:
Combining the existing bulk RNA sequencing and single-cell RNA sequencing (scRNA-seq) data for COVID-19 to obtain a more comprehensive understanding of the role of dysregulated metabolism.
Results:
A total of 19 up-regulated differentially expressed genes (DEGs) and 24 down-regulated genes were selected for subsequent analyses. Nine genes were finally identified with the machine learning method as a potential diagnostic model in both ischemic stroke and COVID-19. In addition, the hub genes were related to both immune infiltration and metabolic pathways.
Conclusions:
Our study revealed the common molecular profile of COVID-19 and ischemic stroke.
