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Hybrid AuNPs-3MPS-MTX nanosystem and its evaluation for treating cervical cancer and melanoma
M J Hernández-Esparza1,2, Ilaria Fratoddi2, Sara Cerra2
1Facultad de Ingeniería Química, Universidad Michoacana de San Nicolás de Hidalgo, Ciudad Universitaria C.P. 58060 Morelia Mexico rafael.huirache@umich.mx.
Abstract:
This research presents an evaluation of a hybrid material based on gold nanoparticles (AuNPs), stabilized with the thiol 3-mercapto-propanesulfonate (3MPS) and loaded with the methotrexate drug (MTX). The AuNPs-3MPS-MTX nanosystem was tested for the treatment of cervical cancer and melanoma, using the B16-F10 melanoma and HeLa cell lines. The tests performed on cell cultures assessed the efficiency of the studied nanosystem on tumor cells, as well as its toxicology.
