Related Experiment Video
Updated: Jul 9, 2025

Characterizing Extracellular Vesicles from Biological Fluids
Published on: February 28, 2025
Signal transduction pathways alter the molecular cargo of extracellular vesicles: implications in regenerative
Prajakta Teli1,2, Anuradha Vaidya1,2, Vaijayanti Kale1,2
1Symbiosis Centre for Stem Cell Research, Symbiosis International (Deemed University), Pune 412115, India.
Abstract:
Extracellular vesicles (EVs) possess regenerative properties and are also considered as future vaccines. All types of cells secrete EVs; however, the amount of EVs secreted by the cells varies under various physiological as well as pathological states. Several articles have reviewed the molecular composition and potential therapeutic applications of EVs. Likewise, the 'sorting signals' associated with specific macromolecules have also been identified, but how the signal transduction pathways prevailing in the parent cells alter the molecular profile of the EVs or the payload they carry has not been sufficiently reviewed. Here, we have specifically discussed the implications of these alterations in the macromolecular cargo of EVs for their therapeutic applications in regenerative medicine.
More Related Videos
Related Concept Videos
Signal Transduction: Overview
Typically, signal transduction involves three...
Diversity in Cell Signaling Responses
Graded and Abrupt Responses
Some signaling systems generate...
Types of Signaling Molecules
Amplifying Signals via Second Messengers
Intracellular Signaling Cascades
Interactions Between Signaling Pathways
Convergence and divergence, and cross-talk between signaling pathways
Two distinct signaling pathways can converge on a single functional unit, which may either be a single protein or a complex of proteins. The response is either functionally distinct or synergistic between the two pathways but different from the response...

