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Published on: September 16, 2019
Nectin-4 has emerged as a compelling target for breast cancer
Hui Wang1, Dejuan Sun1, Jinxia Chen1
1Wuya College of Innovation, Key Laboratory of Structure-Based Drug Design & Discovery, Ministry of Education, Shenyang Pharmaceutical University, Shenyang, 110016, China.
Abstract:
The incidence of breast cancer in women has increased year by year, becoming one of the most common malignant tumors in females worldwide. Most patients can be treated with surgery and endocrine drugs, but there are still some patients who lack effective treatment, such as triple-negative breast cancer (TNBC). Nectin-4, a protein encoded by poliovirus receptor-associated protein 4, is a Ca2+-independent immunoglobulin-like protein. It is mainly involved in the adhesion between cells. In recent years, studies have found that Nectin-4 is overexpressed in breast cancer and several other malignancies. Otherwise, several monoclonal antibodies and inhibitors targeting Nectin-4 have shown prosperous outcomes, so Nectin-4 has great potential to be a therapeutic target for breast cancer. The present review systematically describes the significance of Nectin-4 in each aspect of breast cancer, as well as the molecular mechanisms of these aspects mediated by Nectin-4. We further highlight ongoing or proposed therapeutic strategies for breast cancer specific to Nectin-4.
Insights
Nectin-4 is overexpressed in breast cancer, including triple-negative breast cancer (TNBC). Targeting Nectin-4 with therapies like monoclonal antibodies shows promise for treating this common female malignancy.
Area of Science:
- Oncology
- Molecular Biology
- Immunology
Background:
- Breast cancer incidence is rising globally, posing a significant health challenge.
- Triple-negative breast cancer (TNBC) remains a subtype with limited effective treatment options.
- Nectin-4, a cell adhesion protein, is increasingly recognized for its role in various cancers.
Purpose of the Study:
- To systematically review the significance of Nectin-4 in breast cancer.
- To elucidate the molecular mechanisms underlying Nectin-4's role in breast cancer.
- To highlight Nectin-4-specific therapeutic strategies for breast cancer.
Main Methods:
- Systematic literature review of studies on Nectin-4 and breast cancer.
- Analysis of molecular mechanisms involving Nectin-4 in cancer progression.
- Compilation of current and proposed Nectin-4 targeted therapies.
Main Results:
- Nectin-4 is overexpressed in breast cancer tissues.
- Nectin-4 plays a role in cell adhesion and cancer development.
- Targeting Nectin-4 with antibodies and inhibitors has shown positive therapeutic outcomes.
Conclusions:
- Nectin-4 is a significant factor in breast cancer pathogenesis.
- Nectin-4 represents a promising therapeutic target for breast cancer, particularly TNBC.
- Further development of Nectin-4-targeted therapies could improve patient outcomes.
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