Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Biopharmaceutics and Pharmacokinetics: Overview01:28

Biopharmaceutics and Pharmacokinetics: Overview

2.0K
Understanding drugs, drug products, and their performance in pharmaceutical science is pivotal. Drugs, whether simple molecules or complex compounds, are designed to interact with the body's biological systems to diagnose, treat, or prevent diseases. Drug products include various delivery systems such as tablets, capsules, injections, and inhalers. The performance of these drug products is gauged by their ability to deliver the active ingredient to the desired site of action at the...
2.0K
Inhaled Medications01:23

Inhaled Medications

280
Inhaled medications are crucial for managing chronic obstructive pulmonary disease (COPD) and asthma. They are essential for effective treatment and control, ensuring optimal respiratory health and well-being. Inhaled medication delivers drugs directly to the lungs, providing a rapid onset of action and reducing systemic side effects compared to oral or injectable medications. Three primary types of inhalation devices are used to administer these medications: nebulizers, metered-dose inhalers...
280
Factors Influencing Drug Absorption: Drug Dissolution01:27

Factors Influencing Drug Absorption: Drug Dissolution

521
The pharmacokinetic journey of drugs from solid oral dosage forms into systemic circulation is multifaceted. It begins with disintegration, a prerequisite ensuring a solid dosage form's subdivision into minute particles. Dissolution occurs next as these granulated entities solubilize in gastrointestinal fluids. This solubilization is crucial for the succeeding stage, permeation, which describes the traversal of the drug across the intestinal membrane and its subsequent entry into the blood...
521
Drug Classes and Categories01:25

Drug Classes and Categories

2.0K
Drugs can be classified according to their chemical composition or their intended therapeutic application. For instance, anti-infective agents that possess the ability to eliminate pathogens or suppress their growth and reproduction can be grouped based on the organisms they target or their chemical structure. Furthermore, drugs can be divided into prescription, nonprescription, or controlled substances. Prescription medications, such as antibiotics, require oversight from a licensed healthcare...
2.0K
Hepatic Drug Clearance: Role of Transporters01:14

Hepatic Drug Clearance: Role of Transporters

63
In the liver and bile canaliculi, influx and efflux transporters modification can influence intrinsic clearance. Transporters play a significant role in moving drugs within liver cells. Elaborate models, such as the Biopharmaceutical Classification System (BCS), are essential to relate transporters to drug disposition. This system categorizes drugs into four classes based on solubility and permeability, providing insights into elimination routes and the effects of transporters following oral...
63
Additional Routes of Drug Administration01:18

Additional Routes of Drug Administration

2.8K
Choosing the appropriate route of drug administration is significantly influenced by two key factors: the therapeutic objectives and the inherent properties of the drug being used.
Administering drugs via inhalation allows for the direct delivery of gaseous, volatile substances or droplets to different parts of the respiratory tract. One of the advantages of the inhalation route is the rapid absorption of drugs into the circulatory system, which is possible because of the large surface area of...
2.8K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

An Objective Trigger for Early Palliative Care in Severely Injured Trauma Patients.

The Journal of surgical research·2026
Same author

CaP-Coated Cyclosporine A Liposomes Formulated as an Inhalable Dry Powder for Lung Inflammatory Diseases.

Pharmaceutics·2026
Same author

Dose optimization of inhaled tigecycline in humans to overcome inherent adverse events and maximize bacterial clearance using a physiologically-based pharmacokinetic modeling approach.

Frontiers in tuberculosis·2026
Same author

Perioperative chemotherapy for clinical stage IIIB gallbladder cancer: a review of the National Cancer Database.

International journal of clinical oncology·2026
Same author

Effect of biofilm formation on the antimicrobial activity of tigecycline against <i>Mycobacterium abscessus</i> in the hollow fiber infection model.

Frontiers in microbiology·2026
Same author

Outstanding Contributions to Aerosol Pulmonary Drug Delivery.

Kona : powder science and technology in Japan·2026

Related Experiment Video

Updated: Jul 9, 2025

Dry Powder and Nebulized Aerosol Inhalation of Pharmaceuticals Delivered to Mice Using a Nose-only Exposure System
07:28

Dry Powder and Nebulized Aerosol Inhalation of Pharmaceuticals Delivered to Mice Using a Nose-only Exposure System

Published on: April 6, 2017

40.7K

iBCS: 3. A Biopharmaceutics Classification System for Orally Inhaled Drug Products.

Jayne E Hastedt1, Per Bäckman2, Antonio Cabal3

  • 1JDP Pharma Consulting, San Carlos, California 94070, United States.

Molecular Pharmaceutics
|December 7, 2023
PubMed
Summary

A new quantitative inhalation biopharmaceutics classification system (iBCS) provides guidance for orally inhaled drugs. This system helps manage risks and identify desirable properties for respiratory drug development.

Keywords:
biopharmaceuticsinhalationinhalation biopharmaceutics classification system (iBCS)inhaled medicineslung dissolutionlung doselung permeabilitylung solubility

More Related Videos

Disposable Dosators for Pulmonary Insufflation of Therapeutic Agents to Small Animals
04:22

Disposable Dosators for Pulmonary Insufflation of Therapeutic Agents to Small Animals

Published on: March 30, 2017

7.7K
Author Spotlight: Developing a Disposable Dosator for Preclinical Testing of Dry Powder Inhalers in Small Animal Models
04:59

Author Spotlight: Developing a Disposable Dosator for Preclinical Testing of Dry Powder Inhalers in Small Animal Models

Published on: August 18, 2023

881

Related Experiment Videos

Last Updated: Jul 9, 2025

Dry Powder and Nebulized Aerosol Inhalation of Pharmaceuticals Delivered to Mice Using a Nose-only Exposure System
07:28

Dry Powder and Nebulized Aerosol Inhalation of Pharmaceuticals Delivered to Mice Using a Nose-only Exposure System

Published on: April 6, 2017

40.7K
Disposable Dosators for Pulmonary Insufflation of Therapeutic Agents to Small Animals
04:22

Disposable Dosators for Pulmonary Insufflation of Therapeutic Agents to Small Animals

Published on: March 30, 2017

7.7K
Author Spotlight: Developing a Disposable Dosator for Preclinical Testing of Dry Powder Inhalers in Small Animal Models
04:59

Author Spotlight: Developing a Disposable Dosator for Preclinical Testing of Dry Powder Inhalers in Small Animal Models

Published on: August 18, 2023

881

Area of Science:

  • Pharmaceutical Sciences
  • Biopharmaceutics
  • Drug Delivery

Background:

  • Orally inhaled drug product development historically lacked a biopharmaceutics classification system analogous to oral medicines.
  • Pulmonary physiology complexity, drug deposition/disposition intricacies, and delivery device influence hindered development guidance.
  • The Product Quality Research Institute (PQRI) supported the initiative to create an inhalation biopharmaceutics classification system (iBCS).

Purpose of the Study:

  • To establish a quantitative biopharmaceutics classification system for orally inhaled drugs.
  • To provide inhalation scientists with a "rule of thumb" for desirable molecular properties and CMC risk management.
  • To define iBCS classes quantitatively based on dose number and permeability.

Main Methods:

  • Defined iBCS classes quantitatively using dose number and permeability parameters.
  • Evaluated the proposed iBCS by categorizing marketed inhaled drugs using literature data.
  • Assessed classification appropriateness via published data and physiologically based biopharmaceutics modeling.

Main Results:

  • Successfully categorized marketed inhaled drugs using the quantitative iBCS framework.
  • Discussed and illustrated inhaled drug product development challenges for each iBCS classification.
  • Highlighted the importance of discriminatory laboratory methods for lung deposition, dissolution, and permeability.

Conclusions:

  • The quantitative iBCS offers a valuable tool for streamlining and de-risking inhaled drug development.
  • Understanding physicochemical properties and lung dose is crucial for effective iBCS application.
  • Further development of analytical methods is essential for the full realization of iBCS benefits.