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Updated: Jul 9, 2025
Transthoracic Speckle Tracking Echocardiography for the Quantitative Assessment of Left Ventricular Myocardial Deformation
Published on: October 20, 2016
Myocardial function using two dimension speckle-tracking echocardiography in children with celiac disease
Doaa El Amrousy1, Walid Elshehaby2, Radwa Elsharaby3
1Pediatrics Department, Faculty of Medicine, Tanta University, Tanta, Egypt. doaa.moha@med.tanta.edu.eg.
Insights
Cardiac complications in celiac disease (CD) are increasing. Two dimensional speckle tracking echocardiography (2D-STE) detects early heart dysfunction in children with CD, linked to disease severity and nutritional status.
Area of Science:
- Pediatric Cardiology
- Gastroenterology
- Biomarkers
Background:
- Cardiac complications are an emerging concern in pediatric celiac disease (CD).
- Early detection of myocardial dysfunction in children with CD is crucial.
- Previous research on cardiac function in pediatric CD using advanced echocardiography is limited.
Purpose of the Study:
- To evaluate cardiac function in children with celiac disease using two dimensional speckle tracking echocardiography (2D-STE).
- To identify early signs of myocardial dysfunction in pediatric CD patients.
- To correlate cardiac function parameters with disease duration, severity, and nutritional markers.
Main Methods:
- Cross-sectional study involving 40 children with CD and 40 healthy controls.
- Comprehensive echocardiography including conventional methods, tissue Doppler imaging (TDI), and 2D-STE.
- Biochemical analysis including Hs-troponin T, tTG-IgA, hemoglobin, ferritin, albumin, and vitamin D.
Main Results:
- Conventional echocardiography showed no significant differences between groups.
- 2D-STE revealed significantly lower left ventricular global longitudinal strain (LV GLS) in children with CD.
- Myocardial performance index (MPI) by TDI was higher in children with CD; Hs-troponin T levels were similar.
- LV GLS correlated positively with hemoglobin, ferritin, and albumin, and inversely with disease duration and tTG-IgA.
Conclusions:
- 2D-STE is effective in detecting subclinical cardiac dysfunction in children with CD.
- Cardiac injury in pediatric CD is associated with disease duration, severity, and nutritional deficiencies.
- Early detection and monitoring of cardiac function are recommended for children with celiac disease.
Abstract:
The prevalence of cardiac complications linked to celiac disease (CD) is on expanding. This study aimed to evaluate the cardiac function in children with CD using two dimensional speckle tracking echocardiography (2D-STE) to detect early myocardial dysfunction, if any. This cross-sectional study included 40 children with CD as the patient group and 40 healthy age- and sex-matched children served as the control group. High sensitive troponin T (Hs-troponin T), anti-tissue transglutaminase immunoglobulin A (tTG-IgA), hemoglobin, ferritin, albumin, and vitamin D levels were measured in all participants. Conventional, tissue Doppler imaging (TDI), and 2D-STE were performed for all included children. Conventional echocardiographic parameters showed no significant difference between the two groups. Left ventricular global longitudinal strain (LV GLS) obtained by 2D-STE was substantially lower in children with CD than the control group; however, myocardial performance index (MPI) obtained by TDI was significantly higher in children with CD. Hs-troponin T levels were comparable in both groups. LV GLS was positively correlated with hemoglobin, ferritin, and albumin level, but it was inversely correlated with the duration of the disease and anti tTG-IgA. Conclusion: 2D-STE can detect subclinical early cardiac dysfunction in children with CD and this cardiac injury correlated to the duration and severity of the disease and some nutritional deficiency in these children. What is Known: • The prevalence of cardiac complications linked to celiac disease (CD) is on expanding. • Only one study evaluated cardiac function in children with CD using two dimensional speckle tracking echocardiography (2D-STE). What is New: • Our study found that 2D-STE can detect early subclinical cardiac dysfunction in children with CD. Cardiac injury in theses children correlated to the duration and severity of the disease, hemglobin, ferritin, and albumin levels.
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