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Updated: Jul 9, 2025

Modeling Breast Cancer in Human Breast Tissue using a Microphysiological System
Published on: April 23, 2021
Systems Biology Modeling of Cancer Nonlinear Dynamics
1Heart and Vascular Program, Baystate Health, University of Massachusetts Chan Medical School-Baystate, Springfield, MA, USA.
Abstract:
Not unlike the climate or what holds the galaxies and planetary motions together, cancer biology has an intrinsic nonlinear dynamic. In this overview we will outline how to connect temporal measurements of a nonlinear dynamical and unstable complex system, such as cancer, with well-established engineering methods, old and new, that are applied in linear dynamical systems.This proof-of-concept is therapeutically relevant in the development of new means to treat or control human cancer by either adding an appropriate external "damping" or a "forcing" term, or by a "control" actuator such that its nonlinear dynamic is steered to a spiral stably into zero forever as a sink attractor.
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