Distant Metastatic Microcystic Adnexal Carcinoma

Area of Science:

• Dermatology
• Oncology
• Pathology

Background:

• Microcystic adnexal carcinoma (MAC) is a rare malignant neoplasm of ductal origin.
• MAC is known for local aggressiveness and high recurrence rates, with distant metastasis being uncommon.

Observation:

• A 55-year-old male, post-liver transplant and on immunosuppressants, presented with a growing dermal nodule on his sole.
• Histopathology confirmed the lesion as MAC.
• Eleven months post-excision with clear margins, the patient developed multiple, distant skin nodules.

Findings:

• Histological confirmation of the new lesions also identified them as MAC.
• This case demonstrates a rare occurrence of distant metastasis in microcystic adnexal carcinoma.

Implications:

• The findings suggest that immunosuppression may play a role in the metastatic potential of MAC.
• Highlights the importance of vigilant follow-up for patients with MAC, especially those who are immunosuppressed.
• Underscores the need for further research into the behavior and risk factors for metastasis in MAC.