Related Experiment Video
Updated: Jul 9, 2025

12:04
The bm12 Inducible Model of Systemic Lupus Erythematosus SLE in C57BL/6 Mice
Published on: November 1, 2015
17.6K
Methotrexate-Induced Accelerated Nodulosis in a Patient with Systemic Lupus Erythematosus
Hyeong Mok Kwon1, Eun Hye Jeong1, Jung Eun Yim1
1Department of Dermatology, Yeungnam University College of Medicine, Daegu, Korea.
Annals of Dermatology
|December 7, 2023
Summary
Methotrexate (MTX)-induced accelerated nodulosis (MIAN) can occur in patients with systemic lupus erythematosus (SLE). Discontinuing MTX led to the resolution of MIAN in a SLE patient, highlighting the importance of accurate diagnosis.
Area of Science:
- Rheumatology
- Dermatology
- Pathology
Background:
- Methotrexate (MTX)-induced accelerated nodulosis (MIAN) is a rare adverse effect of MTX therapy, typically seen in rheumatoid arthritis patients.
- MIAN has also been reported in patients with other autoinflammatory conditions, including systemic lupus erythematosus (SLE).
- Accurate differentiation from rheumatoid nodules is crucial due to similar clinicopathological features.

